{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T18:21:42Z","timestamp":1772994102347,"version":"3.50.1"},"reference-count":15,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,8,21]],"date-time":"2025-08-21T00:00:00Z","timestamp":1755734400000},"content-version":"vor","delay-in-days":232,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Case Reports in Hematology"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:p>\n                    <jats:bold>Background:<\/jats:bold>\n                    Factor X (FX) deficiency is a rare autosomal recessive inherited bleeding disorder, with an estimated prevalence of approximately 1 in 1,000,000 individuals. According to the most recent data published by the World Federation of Hemophilia, no cases of FX deficiency have been reported in Cambodia to date.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Case Report:<\/jats:bold>\n                    A 14\u2010year\u2010 and 7\u2010month\u2010old Cambodian boy presented with recurrent gum bleeding. His medical history was notable for multiple hematomas, joint ankylosis, and blue sclera. He was born to second\u2010degree consanguineous parents, with no known family history of bleeding disorders. Laboratory evaluation revealed prolonged prothrombin time (PT) and activated partial thromboplastin time (APTT) and severely reduced FX activity (&lt; 1%), consistent with a diagnosis of severe congenital FX deficiency. Bleeding was successfully managed with fresh frozen plasma, initially administered at 15\u2009mL\/kg, followed by maintenance doses of 5\u2009mL\/kg twice daily.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusion:<\/jats:bold>\n                    FX deficiency, though rare, should be considered in the differential diagnosis of pediatric patients presenting with recurrent gingival or mucocutaneous bleeding in conjunction with prolonged PT and APTT. This consideration is particularly important in resource\u2010limited settings such as Cambodia, especially in children born to consanguineous parents and after more common coagulopathies have been excluded. In low\u2010resource settings, where FX concentrates are often unavailable or unaffordable, fresh frozen plasma remains the primary treatment option.\n                  <\/jats:p>","DOI":"10.1155\/crh\/5592395","type":"journal-article","created":{"date-parts":[[2025,8,21]],"date-time":"2025-08-21T12:49:32Z","timestamp":1755780572000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Severe Congenital Factor X Deficiency as a First Case Report in Cambodia"],"prefix":"10.1155","volume":"2025","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-1111-6416","authenticated-orcid":false,"given":"Chin","family":"Soey","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-0884-4921","authenticated-orcid":false,"given":"Meang","family":"Sovandos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lam","family":"Pechkethia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lean","family":"Kimsreng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-6954-0492","authenticated-orcid":false,"given":"Chean","family":"Soph\u00e2l","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,8,21]]},"reference":[{"key":"e_1_2_11_1_2","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/9657516"},{"key":"e_1_2_11_2_2","unstructured":"National Bleeding Disorders Foundation Factor X: An Overview of Symptoms Genetics and Treatments to Help You Understand Factor X Deficiency 2025 https:\/\/www.hemophilia.org\/bleeding-disorders-a-z\/types\/other-factor-deficiencies\/factor-x."},{"key":"e_1_2_11_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-08-100601-6.00067-3"},{"key":"e_1_2_11_4_2","doi-asserted-by":"publisher","DOI":"10.1182\/asheducation-2016.1.663"},{"key":"e_1_2_11_5_2","unstructured":"National Organization for Rare Disorders Factor X Deficiency 2025 https:\/\/rarediseases.org\/rare-diseases\/factor-x-deficiency\/."},{"key":"e_1_2_11_6_2","unstructured":"World Federation of Hemophilia Report on the Annual Global Survey 2021 2022 https:\/\/www1.wfh.org\/publications\/files\/pdf-2324."},{"key":"e_1_2_11_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/B0-12-370879-6\/00085-5"},{"key":"e_1_2_11_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-382219-2.00642-6"},{"key":"e_1_2_11_9_2","volume-title":"Physiology, Clotting Mechanism","author":"Garmo C."},{"key":"e_1_2_11_10_2","doi-asserted-by":"publisher","DOI":"10.15406\/ipcb.2017.02.00008"},{"key":"e_1_2_11_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-323-35762-3.00137-2"},{"key":"e_1_2_11_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2011.02724.x"},{"key":"e_1_2_11_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.blre.2021.100833"},{"key":"e_1_2_11_14_2","doi-asserted-by":"publisher","DOI":"10.1111\/hae.13500"},{"key":"e_1_2_11_15_2","doi-asserted-by":"publisher","DOI":"10.2478\/jhp-2023-0015"}],"container-title":["Case Reports in 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