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Recently, CAR\u2010T cell therapy targeting G\u2010protein\u2010coupled receptor, class C group 5 member D (GPRC5D) has shown promising efficacy and safety in preclinical studies, offering new hope for patients with RRMM. We report the successful treatment of a 48\u2010year\u2010old female patient with relapsed\/refractory nonsecretory MM. The patient had high\u2010risk factors, including 1q21 amplification and TP53 deletion, and had relapsed after seven lines of therapy, including autologous hematopoietic stem cell transplantation, proteasome inhibitors, immunomodulatory agents, PD\u20101 inhibitors, and CD38 monoclonal antibodies. She also developed extramedullary disease. Eventually, she received CAR\u2010T cell therapy targeting GPRC5D, which led to the complete disappearance of extramedullary lesions and a sustained complete remission lasting up to 17\u2009months. In conclusion, CAR\u2010T cell therapy targeting GPRC5D is highly effective and well\u2010tolerated in patients with RRMM, especially those with high\u2010risk factors. Further studies with larger cohorts and longer follow\u2010up periods are needed to validate the clinical application of GPRC5D\u2010targeted CAR\u2010T cell therapy in RRMM, particularly for patients who have failed BCMA\u2010targeted therapies.<\/jats:p>","DOI":"10.1155\/crh\/5900306","type":"journal-article","created":{"date-parts":[[2025,12,15]],"date-time":"2025-12-15T12:03:41Z","timestamp":1765800221000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Targeting GPRC5D With CAR\u2010T Cells in Relapse\/Refractory Multiple Myeloma: Case Report and Literature 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