{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T15:23:50Z","timestamp":1753889030641,"version":"3.41.2"},"reference-count":17,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,11,16]],"date-time":"2024-11-16T00:00:00Z","timestamp":1731715200000},"content-version":"vor","delay-in-days":320,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Case Reports in Hematology"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:p>We describe the case of a 27\u2010year\u2010old male, previously healthy though with a social history notable for recreational cocaine use, who developed bone marrow failure due to aplastic anemia (AA) with associated serous fat atrophy (SFA). After the SFA was corrected with nutritional supplementation, the patient underwent successful allogeneic, haploidentical stem cell transplantation with a regimen designed to treat AA. To our knowledge, this is the first case of hematopoietic stem cell transplantation (HSCT) performed following correction of SFA. Herein we propose our novel hypothesis that SFA, once resolved, is not a contraindication to stem cell transplantation, which we believe adds valuable insight toward an improved understanding of nutrition\u2019s role in HSCT. Additionally, the AA is thought to be toxin\u2010induced and specifically levamisole\u2010mediated after exposure to levamisole\u2010adulterated cocaine. We highlight potential connections between levamisole, AA, and SFA and call for further efforts to understand these relationships\u2014especially as the use of levamisole as a cocaine adulterant continues to rise across the globe.<\/jats:p>","DOI":"10.1155\/crh\/6526961","type":"journal-article","created":{"date-parts":[[2024,11,16]],"date-time":"2024-11-16T09:48:42Z","timestamp":1731750522000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Bone Marrow Failure due to Aplastic Anemia, Associated With Serous Fat Atrophy, and Treated With Allogeneic, Haploidentical Stem Cell Transplantation: A Case Report"],"prefix":"10.1155","volume":"2024","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1553-4991","authenticated-orcid":false,"given":"Matthew J.","family":"Pisarcik","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cameron J.","family":"Oswalt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eric D.","family":"Carlsen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9863-8464","authenticated-orcid":false,"given":"Mitchell E.","family":"Horwitz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,11,16]]},"reference":[{"key":"e_1_2_9_1_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1413485"},{"key":"e_1_2_9_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S2352-3026(22)00206-X"},{"key":"e_1_2_9_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-200001000-00007"},{"key":"e_1_2_9_4_2","first-page":"585","article-title":"Clinical Profile in Gelatinous Bone Marrow Transformation","volume":"51","author":"Sen R.","year":"2003","journal-title":"Journal of the Association of Physicians of India"},{"key":"e_1_2_9_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/eat.20833"},{"key":"e_1_2_9_6_2","doi-asserted-by":"publisher","DOI":"10.4322\/acr.2017.039"},{"key":"e_1_2_9_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12288-015-0514-5"},{"key":"e_1_2_9_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mayocp.2012.03.010"},{"key":"e_1_2_9_9_2","doi-asserted-by":"publisher","DOI":"10.1309\/2Y7X-YDXK-006B-XLT2"},{"key":"e_1_2_9_10_2","doi-asserted-by":"publisher","DOI":"10.1155\/2024\/2044820"},{"key":"e_1_2_9_11_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00204-017-1947-4"},{"key":"e_1_2_9_12_2","doi-asserted-by":"publisher","DOI":"10.1124\/dmd.112.045021"},{"key":"e_1_2_9_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/mpo.2950240409"},{"key":"e_1_2_9_14_2","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.13761"},{"key":"e_1_2_9_15_2","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/276862"},{"key":"e_1_2_9_16_2","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2018.00694"},{"key":"e_1_2_9_17_2","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2018.00587"}],"container-title":["Case Reports in Hematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/crh\/6526961","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,16]],"date-time":"2024-11-16T09:48:44Z","timestamp":1731750524000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/crh\/6526961"}},"subtitle":[],"editor":[{"given":"Pier Paolo","family":"Piccaluga","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2024,1]]},"references-count":17,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2024,1]]}},"alternative-id":["10.1155\/crh\/6526961"],"URL":"https:\/\/doi.org\/10.1155\/crh\/6526961","archive":["Portico"],"relation":{},"ISSN":["2090-6560","2090-6579"],"issn-type":[{"type":"print","value":"2090-6560"},{"type":"electronic","value":"2090-6579"}],"subject":[],"published":{"date-parts":[[2024,1]]},"assertion":[{"value":"2024-04-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-09-24","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-11-16","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"6526961"}}