{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T04:07:56Z","timestamp":1779077276689,"version":"3.51.4"},"reference-count":17,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,5,17]],"date-time":"2026-05-17T00:00:00Z","timestamp":1778976000000},"content-version":"vor","delay-in-days":136,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Case Reports in Hematology"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:p>Rosai\u2013Dorfman disease (RDD) can present with lymphadenopathy. However, it is important to note that RDD can also coexist with hematologic malignancies, including non\u2010Hodgkin lymphomas. We present a case of an older male patient with generalized lymphadenopathy who was first diagnosed with RDD. High\u2010dose steroid therapy was rendered without a satisfactory response. Thus, the tissue specimens were re\u2010examined, and the patient was found to have diffuse large B\u2010cell lymphoma (DLBCL) in the background of RDD. The laboratory tests are notable for a slightly elevated serum lactate dehydrogenase (LDH) level. A positron emission tomography\u2010computed tomography scan revealed generalized hypermetabolic lymphadenopathy above and below the diaphragm. A bone marrow biopsy showed normocellular marrow without evidence of DLBCL. The international prognostic index score was 3 (age &gt;\u200960\u2009years, elevated serum LDH level, and Stage III disease), indicating a high\u2010intermediate risk disease. The patient was treated with six cycles of golcadomide in combination with R\u2010Pola\u2010CHP (rituximab, polatuzumab vedotin, cyclophosphamide, doxorubicin, and prednisone) for the underlying DLBCL, with resolution of both DLBCL and RDD. The disease remained in remission at the follow\u2010up visit 9\u2009months after completing the therapy. This case highlights the importance of recognizing underlying DLBCL in patients with RDD for optimal patient outcomes.<\/jats:p>\n                  <jats:p>\n                    <jats:bold>Trial Registration:<\/jats:bold>\n                    ClinicalTrials.gov identifier: NCT04884035\n                  <\/jats:p>","DOI":"10.1155\/crh\/6560267","type":"journal-article","created":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T03:44:27Z","timestamp":1779075867000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Diffuse Large B\u2010Cell Lymphoma Presenting in a Background of Rosai\u2013Dorfman Disease"],"prefix":"10.1155","volume":"2026","author":[{"given":"Chao","family":"Wu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anders","family":"Meyer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5245-2354","authenticated-orcid":false,"given":"Aung M.","family":"Tun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,5,17]]},"reference":[{"key":"e_1_2_9_1_2","doi-asserted-by":"publisher","DOI":"10.1136\/jclinpath-2020-206733"},{"key":"e_1_2_9_2_2","doi-asserted-by":"publisher","DOI":"10.1186\/1752-1947-2-70"},{"key":"e_1_2_9_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S2152-2650(24)01479-4"},{"key":"e_1_2_9_4_2","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.43.741"},{"key":"e_1_2_9_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.annonc.a010804"},{"key":"e_1_2_9_6_2","first-page":"66","article-title":"A Case of Sinus Histiocytosis With Massive Lymphadenopathy (Rosai-Dorfman Disease) in a Patient with Diffuse Large B-Cell Lymphoma and Chronic Hepatitis B Virus Infection","volume":"84","author":"Melikian A.","year":"2012","journal-title":"Terapevticheskii 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