{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T04:47:08Z","timestamp":1782276428560,"version":"3.54.5"},"reference-count":37,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T00:00:00Z","timestamp":1782172800000},"content-version":"vor","delay-in-days":173,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Case Reports in Hematology"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>T\u2010cell lymphomas are rare, comprising 10%\u201315% of non\u2010Hodgkin lymphomas (NHLs). Their etiology remains unclear, and pathophysiology varies widely among subtypes. Sarcoid\u2010like reactions (SLRs) have been reported in approximately 7.3% of NHLs, including T\u2010cell lymphomas, and can closely resemble sarcoidosis clinically\/histologically. This overlap complicates diagnosis, particularly when secondary myelofibrosis\u2014a rare and poorly understood complication\u2014arises. Myelofibrosis has also been observed in sarcoidosis, further blurring the distinction between these entities. Treatment for T\u2010cell lymphoma\u2010associated secondary myelofibrosis is not standardized, with predominantly CHOP\u2010based regimens showing variable efficacy. This warrants further research to guide diagnostic and management frameworks.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case Description<\/jats:title>\n                    <jats:p>We report the case of a 57\u2010year\u2010old male with known systemic sarcoidosis who developed recurrent symptomatic hypercalcemia and new\u2010onset transfusion\u2010dependent pancytopenia. Initial evaluation revealed bone marrow fibrosis with noncaseating granulomas, raising concern for sarcoidosis\u2010driven secondary myelofibrosis. However, repeat bone marrow biopsy demonstrated T\u2010cell lymphoma with a SLR. Primary myelofibrosis was excluded, supporting a secondary lymphoma\u2010driven process. The patient is currently undergoing treatment with BV\u2010CHP with close hematologic monitoring.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>T\u2010cell lymphoma\u2010associated SLR can closely mimic sarcoidosis and should be considered in the differential, particularly in patients with atypical presentations or cytopenias. Despite similar clinical and histological features, the underlying pathophysiology differs, necessitating thorough molecular and immunophenotypic evaluation. Though rare, this entity can lead to secondary myelofibrosis, underscoring the importance of excluding a primary myeloproliferative process. Further research is needed to define optimal therapy, with BV\u2010CHP representing a promising option in the evolving landscape of T\u2010cell lymphoma management.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1155\/crh\/6857208","type":"journal-article","created":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T03:59:32Z","timestamp":1782273572000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["T\u2010Cell Lymphoma With Sarcoid\u2010Like Reaction and Secondary Myelofibrosis: A Unique Case Report and Literature Review"],"prefix":"10.1155","volume":"2026","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-9333-1123","authenticated-orcid":false,"given":"Renee","family":"Morecroft","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-3291-3231","authenticated-orcid":false,"given":"Azalfa","family":"Lateef","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-1690-0539","authenticated-orcid":false,"given":"Joseph Brandon","family":"Parker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-4157-706X","authenticated-orcid":false,"given":"Rachel","family":"Sauls","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9156-3567","authenticated-orcid":false,"given":"Jordan","family":"Phillipps","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2310-7655","authenticated-orcid":false,"given":"Patricia","family":"Chipi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4849-4279","authenticated-orcid":false,"given":"Emily","family":"Wolf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Candido","family":"Rivera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kirk","family":"Bourgeois","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3627-4399","authenticated-orcid":false,"given":"Vikas","family":"Majithia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1015-1633","authenticated-orcid":false,"given":"Sehreen","family":"Mumtaz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,23]]},"reference":[{"key":"e_1_2_13_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/J.PRP.2024.155769"},{"key":"e_1_2_13_2_2","doi-asserted-by":"publisher","DOI":"10.3389\/FONC.2023.1150715"},{"key":"e_1_2_13_3_2","volume-title":"How Common is Lymphoma? | Key Statistics for Non-Hodgkin Lymphoma","year":"2025"},{"key":"e_1_2_13_4_2","doi-asserted-by":"publisher","DOI":"10.1182\/BLOOD-2017-11-764357"},{"key":"e_1_2_13_5_2","doi-asserted-by":"publisher","DOI":"10.1146\/ANNUREV-PATHOL-020117-043821"},{"key":"e_1_2_13_6_2","doi-asserted-by":"publisher","DOI":"10.3389\/FMED.2020.594118"},{"key":"e_1_2_13_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.1986.199"},{"key":"e_1_2_13_8_2","doi-asserted-by":"crossref","unstructured":"LondonJ. elie GradosA. 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