{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T18:21:48Z","timestamp":1772994108147,"version":"3.50.1"},"reference-count":17,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,6,27]],"date-time":"2025-06-27T00:00:00Z","timestamp":1750982400000},"content-version":"vor","delay-in-days":177,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Case Reports in Hematology"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:p>\n                    Myeloid\/lymphoid neoplasms with eosinophilia and tyrosine kinase gene fusions (MLN\u2010TK) represent rare hematological malignancies driven by pathological fusion genes involving tyrosine kinase genes. Among these, rearrangements of the\n                    <jats:italic>PDGFRB<\/jats:italic>\n                    gene, particularly the\n                    <jats:italic>ETV6::PDGFRB<\/jats:italic>\n                    rearrangement, are frequently observed as pathogenic mutations. Conversely, instances of the\n                    <jats:italic>MPRIP::PDGFRB<\/jats:italic>\n                    fusion gene are rarely documented. In this case report, we present a 32\u2010year\u2010old previously healthy Thai male who presented to the hospital with constitutional symptoms and marked splenomegaly. His complete blood count revealed mild anemia, marked leukocytosis with hypereosinophilia, and mild thrombocytopenia. A bone marrow study showed hypercellular marrow with granulocytic hyperplasia extensively involved with eosinophils, without morphological evidence of blasts. Conventional cytogenetics identified a t (5; 17) (q33; p13). Further targeted RNA analysis using next\u2010generation sequencing (NGS) detected a fusion gene involving\n                    <jats:italic>MPRIP::PDGFRB<\/jats:italic>\n                    . The patient was diagnosed with myeloid\/lymphoid neoplasms with eosinophilia and\n                    <jats:italic>MPRIP::PDGFRB<\/jats:italic>\n                    rearrangement in the chronic\u2010phase disease and was initiated on oral imatinib at a daily dose of 100\u2009mg. One month after initiating the treatment, the patient achieved a hematological response consistent with complete response (CR) criteria. Imatinib therapy has been well\u2010tolerated without reported adverse events, and a 1\u2010year molecular assessment confirmed the achievement of complete molecular response (CMR).\n                  <\/jats:p>","DOI":"10.1155\/crh\/7098722","type":"journal-article","created":{"date-parts":[[2025,6,28]],"date-time":"2025-06-28T01:32:57Z","timestamp":1751074377000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["<i>MPRIP::PDGFRB<\/i>\n                    Fusion Gene: A Rare Case Report of Adult Myeloid\/Lymphoid Neoplasm With Eosinophilia and Tyrosine Kinase Gene Fusions"],"prefix":"10.1155","volume":"2025","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-3752-4007","authenticated-orcid":false,"given":"Taksin","family":"Ukkahad","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0528-4076","authenticated-orcid":false,"given":"Tanapun","family":"Thamgrang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,6,27]]},"reference":[{"key":"e_1_2_10_1_2","volume-title":"WHO Classification of Tumours Series","author":"WHO Classification of Tumours Editorial Board","year":"2024"},{"key":"e_1_2_10_2_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2022015850"},{"key":"e_1_2_10_3_2","doi-asserted-by":"publisher","DOI":"10.1186\/s40164-019-0136-y"},{"key":"e_1_2_10_4_2","first-page":"493","article-title":"Differential Diagnosis of the Eosinophilia-Myalgia Syndrome and Idiopathic Eosinophilia by Cytokine Gene Expression Analysis","volume":"35","author":"Reiter A.","year":"2013","journal-title":"The International Journal of Literary Humanities"},{"key":"e_1_2_10_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41375-023-01859-3"},{"key":"e_1_2_10_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41375-023-01958-1"},{"key":"e_1_2_10_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00277-017-3067-x"},{"key":"e_1_2_10_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2404728"},{"key":"e_1_2_10_9_2","doi-asserted-by":"publisher","DOI":"10.1159\/000046641"},{"key":"e_1_2_10_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/gcc.22287"},{"key":"e_1_2_10_11_2","doi-asserted-by":"publisher","DOI":"10.5430\/dcc.v8n3p1"},{"key":"e_1_2_10_12_2","first-page":"3038","article-title":"FIP1L1\u2013PDGFRA Fusion: Prevalence and Molecular Characterization in Hypereosinophilic Syndrome and Chronic Eosinophilic Leukemia","volume":"104","author":"Jan C.","year":"2004","journal-title":"Blood"},{"key":"e_1_2_10_13_2","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2020.249649"},{"key":"e_1_2_10_14_2","doi-asserted-by":"publisher","DOI":"10.1097\/hs9.0000000000000250"},{"key":"e_1_2_10_15_2","article-title":"How I (Diagnose and) Treat Myeloid\/Lymphoid Neoplasms With Tyrosine Kinase Gene Fusions","author":"Reiter A.","year":"2024","journal-title":"Blood"},{"key":"e_1_2_10_16_2","doi-asserted-by":"publisher","DOI":"10.6004\/jnccn.2020.0042"},{"key":"e_1_2_10_17_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2014-02-555607"}],"container-title":["Case Reports in Hematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/crh\/7098722","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1155\/crh\/7098722","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/crh\/7098722","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T15:04:24Z","timestamp":1772982264000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/crh\/7098722"}},"subtitle":[],"editor":[{"given":"Stephen 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