{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T19:06:13Z","timestamp":1772996773230,"version":"3.50.1"},"reference-count":11,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T00:00:00Z","timestamp":1772755200000},"content-version":"vor","delay-in-days":64,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Case Reports in Hematology"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:p>\n                    Follicular lymphoma (FL) is an indolent but incurable B\u2010cell malignancy, typically requiring therapy in patients with high tumor burden. Although spontaneous regression has been described, its frequency and durability are uncertain and require longitudinal follow\u2010up. We report a 64\u2010year\u2010old man with high\u2010burden FL fulfilling GELF criteria who deferred treatment and subsequently demonstrated a marked spontaneous metabolic response on a follow\u2010up [\n                    <jats:sup>18<\/jats:sup>\n                    F]FDG PET\/CT over a 6\u2010month follow\u2010up period. The metabolic response encompassed nodal, splenic, and serosal involvement, accompanied by resolution of symptoms and improvement in laboratory parameters. This case highlights the biological heterogeneity of FL and emphasizes the importance of individualized management and ongoing surveillance.\n                  <\/jats:p>","DOI":"10.1155\/crh\/7545774","type":"journal-article","created":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T16:10:43Z","timestamp":1772986243000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Spontaneous Metabolic Regression in High\u2010Burden Follicular Lymphoma: A Case Report"],"prefix":"10.1155","volume":"2026","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3026-8724","authenticated-orcid":false,"given":"Yotam","family":"Bronstein","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9843-8817","authenticated-orcid":false,"given":"Roy","family":"Vitkon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucille","family":"Hayman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chava","family":"Perry","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,3,6]]},"reference":[{"key":"e_1_2_11_1_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41375-025-02603-9"},{"key":"e_1_2_11_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.26737"},{"key":"e_1_2_11_3_2","doi-asserted-by":"publisher","DOI":"10.1200\/jco.1997.15.3.1110"},{"key":"e_1_2_11_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0140-6736(03)14110-4"},{"key":"e_1_2_11_5_2","unstructured":"NCCN Guidelines Version 1.2026 B-Cell Lymphomas."},{"key":"e_1_2_11_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19800515)45:10<2627::AID-CNCR2820451023>3.0.CO;2-0"},{"key":"e_1_2_11_7_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198412063112303"},{"key":"e_1_2_11_8_2","doi-asserted-by":"publisher","DOI":"10.1097\/00003072-200411000-00002"},{"key":"e_1_2_11_9_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2009-04-217687"},{"key":"e_1_2_11_10_2","first-page":"35","article-title":"Spontaneous Regression of Hematologic Cancers","volume":"44","author":"Wiernik P. 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