{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T18:21:56Z","timestamp":1772994116441,"version":"3.50.1"},"reference-count":10,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,7,3]],"date-time":"2025-07-03T00:00:00Z","timestamp":1751500800000},"content-version":"vor","delay-in-days":183,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Case Reports in Hematology"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:p>Early T\u2010cell precursor acute lymphoblastic leukemia\/lymphoma (ETP\u2010ALL\/LBL) is a high\u2010risk and biologically distinct subset of T\u2010cell acute lymphoblastic leukemia, typically characterized by leukemic involvement of bone marrow, peripheral blood, and mediastinal structures. Central nervous system (CNS) involvement is typically a secondary manifestation [1, 2, 3]. We report a rare case of isolated CNS presentation of ETP\u2010ALL\/LBL in a 73\u2010year\u2010old woman who presented with progressive neurological symptoms. Imaging revealed a large right frontal extra\u2010axial mass. Systemic evaluation, including peripheral blood flow cytometry and CT imaging of chest, abdomen, and pelvis, showed no evidence ofsystemic disease. Surgical resection and subsequent histopathology confirmed the diagnosis of ETP\u2010ALL\/LBL. A bone marrow biopsy was deffered to the patient\u2019s preference and rapid clinical deterioration. This case underscores the diagnostic and therapeutic challenges of CNS\u2010restricted leukemic presentations and highlights the need for early recognition and CNS\u2010directed diagnostic evaluation.<\/jats:p>","DOI":"10.1155\/crh\/7634316","type":"journal-article","created":{"date-parts":[[2025,7,4]],"date-time":"2025-07-04T01:33:10Z","timestamp":1751592790000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Isolated Central Nervous System Presentation of Early T\u2010Cell Precursor Acute Lymphoblastic Leukemia\/Lymphoma: A Rare Case of Exclusive Brain Involvement"],"prefix":"10.1155","volume":"2025","author":[{"given":"Violet O.","family":"Swart","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1650-7805","authenticated-orcid":false,"given":"Behyar","family":"Zoghi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,7,3]]},"reference":[{"key":"e_1_2_8_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.blre.2016.09.004"},{"key":"e_1_2_8_2_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2015-08-661702"},{"key":"e_1_2_8_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/s1470-2045(08)70314-0"},{"key":"e_1_2_8_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.12882"},{"key":"e_1_2_8_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2011.08955.x"},{"key":"e_1_2_8_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature10725"},{"key":"e_1_2_8_7_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2012-11-465138"},{"key":"e_1_2_8_8_2","doi-asserted-by":"publisher","DOI":"10.1200\/jco.2016.71.8585"},{"key":"e_1_2_8_9_2","doi-asserted-by":"publisher","DOI":"10.1056\/nejmoa1403088"},{"key":"e_1_2_8_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.14474"}],"container-title":["Case Reports in Hematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/crh\/7634316","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1155\/crh\/7634316","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/crh\/7634316","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T15:05:16Z","timestamp":1772982316000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/crh\/7634316"}},"subtitle":[],"editor":[{"given":"Yoshito","family":"Nishimura","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2025,1]]},"references-count":10,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,1]]}},"alternative-id":["10.1155\/crh\/7634316"],"URL":"https:\/\/doi.org\/10.1155\/crh\/7634316","archive":["Portico"],"relation":{},"ISSN":["2090-6560","2090-6579"],"issn-type":[{"value":"2090-6560","type":"print"},{"value":"2090-6579","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1]]},"assertion":[{"value":"2025-04-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-05-22","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-07-03","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"7634316"}}