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In most cases, patients suffering from multiple myeloma typically display normal or decreased blood lipid concentrations. We herein present a case of immunoglobulin (Ig) D\u2010\u03bb subtype multiple myeloma with concurrent hyperlipidemia. This patient presented with elevated lipid levels upon lenalidomide, bortezomib, and dexamethasone (RVD) chemotherapy with triglycerides of 4.12\u2009mmol\/L (reference range: 0.4\u20131.7\u2009mmol\/L), total cholesterol of 6.71\u2009mmol\/L (reference range: 3.12\u20135.72\u2009mmol\/L), low\u2010density lipoprotein cholesterol of 4.29\u2009mmol\/L (reference range: 1.04\u20131.96\u2009mmol\/L), and lipoprotein(a) of 582\u2009mg\/L (reference range: 0\u2013300\u2009mg\/L), which showed typical symptoms of hyperlipidemia. After chemotherapy cycles, the elevated lipid indicators were gradually decreased (or close) to normal levels without any antihyperlipidemia drug or therapy. This report analyzed a rare hyperlipidemic multiple myeloma case and may provide insights into the safety and guidance of the procedure for clinical diagnosis and treatment.<\/jats:p>","DOI":"10.1155\/crh\/9065226","type":"journal-article","created":{"date-parts":[[2026,4,18]],"date-time":"2026-04-18T04:30:52Z","timestamp":1776486652000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A Rare Case Report of Immunoglobulin D Subtype Multiple Myeloma Complicated With 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