{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T18:22:05Z","timestamp":1772994125110,"version":"3.50.1"},"reference-count":12,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,5,20]],"date-time":"2025-05-20T00:00:00Z","timestamp":1747699200000},"content-version":"vor","delay-in-days":139,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Case Reports in Hematology"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:p>\n                    <jats:bold>Introduction:<\/jats:bold>\n                    This case report describes a 17\u2010year\u2010old female patient who initially presented with vaginal bleeding, weight loss, and nonspecific symptoms, which led to the diagnosis of B\u2010cell acute lymphoblastic leukemia (B\u2010ALL). This unusual presentation highlights the importance of considering hematological malignancies in patients with atypical symptoms.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Case Presentation:<\/jats:bold>\n                    The patient, married for 2\u2009weeks, experienced vaginal bleeding following her first sexual intercourse, which did not resolve spontaneously. She also reported a 6\u2009kg weight loss over the past 3\u20104\u2009months, hair loss, and a history of dysmenorrhea and an ovarian cyst detected 2\u2009years prior. Laboratory investigations revealed leukocytosis (WBC: 16,500\/\u03bcL), anemia (Hb: 11.4\u2009g\/dL), and thrombocytopenia (Plt: 44,000\/\u03bcL). Bone marrow aspiration (BMA) and flow cytometry confirmed the diagnosis of B\u2010ALL, revealing a high percentage of atypical lymphoid cells.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Discussion:<\/jats:bold>\n                    This case underscores the rarity of diagnosing hematological malignancies in patients with vaginal bleeding. The patient\u2019s symptoms, including weight loss and thrombocytopenia, should have prompted a more comprehensive evaluation. Early recognition of B\u2010ALL is crucial as prompt treatment significantly improves outcomes. The patient was started on prednisolone and alkalinized fluids, and her condition was closely monitored.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusion:<\/jats:bold>\n                    Vaginal bleeding in young patients should not be dismissed as a minor issue, especially when accompanied by other systemic symptoms like weight loss and thrombocytopenia. Early diagnosis of B\u2010ALL in such cases can lead to better management and prognosis.\n                  <\/jats:p>","DOI":"10.1155\/crh\/9949125","type":"journal-article","created":{"date-parts":[[2025,5,20]],"date-time":"2025-05-20T07:20:28Z","timestamp":1747725628000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Unusual Presentation of Childhood Leukemia With Vaginal Bleeding: A Case Report"],"prefix":"10.1155","volume":"2025","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0008-303X","authenticated-orcid":false,"given":"\u015eule","family":"\u00c7al\u0131\u015fkan Kam\u0131\u015f","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,5,20]]},"reference":[{"key":"e_1_2_12_1_2","doi-asserted-by":"publisher","DOI":"10.4274\/jcrpe.0014"},{"key":"e_1_2_12_2_2","doi-asserted-by":"publisher","DOI":"10.1097\/pec.0000000000001694"},{"key":"e_1_2_12_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/ms9.0000000000000140"},{"key":"e_1_2_12_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/s2152-2650(22)01172-7"},{"key":"e_1_2_12_5_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12920-022-01169-0"},{"key":"e_1_2_12_6_2","article-title":"Acute Lymphoblastic Leukemia (ALL): A Literature Review on Pediatric Population","volume":"2","author":"Soares L.","year":"2024","journal-title":"Leukemia"},{"key":"e_1_2_12_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-024-00525-x"},{"key":"e_1_2_12_8_2","volume-title":"Sole\u2019s Introduction to Critical Care Nursing","author":"Smith L.","year":"2024"},{"key":"e_1_2_12_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.28371"},{"key":"e_1_2_12_10_2","volume-title":"Hematopathology","author":"Wilson C. S.","year":"2010"},{"key":"e_1_2_12_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.27961"},{"key":"e_1_2_12_12_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0294438"}],"container-title":["Case Reports in Hematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/crh\/9949125","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1155\/crh\/9949125","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/crh\/9949125","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T15:04:06Z","timestamp":1772982246000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/crh\/9949125"}},"subtitle":[],"editor":[{"given":"Kalyani","family":"Sen","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2025,1]]},"references-count":12,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,1]]}},"alternative-id":["10.1155\/crh\/9949125"],"URL":"https:\/\/doi.org\/10.1155\/crh\/9949125","archive":["Portico"],"relation":{},"ISSN":["2090-6560","2090-6579"],"issn-type":[{"value":"2090-6560","type":"print"},{"value":"2090-6579","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1]]},"assertion":[{"value":"2024-12-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-05-13","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-05-20","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"9949125"}}