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VBDS involves the progressive disappearance of intrahepatic bile ducts, causing cholestasis and biliary cirrhosis, with high mortality if untreated. VBDS can also present as a paraneoplastic syndrome in Hodgkin\u2019s lymphoma (HL). A 53\u2010year\u2010old female presented with jaundice, pruritus, diarrhea, and elevated liver function tests (LFTs). A liver biopsy demonstrated cholestasis with mild ductopenia, and imaging revealed enlarged para\u2010aortic lymph nodes. A bone marrow biopsy confirmed HL, and chemotherapy normalized symptoms and LFTs.<\/jats:p>","DOI":"10.1155\/crhe\/4166844","type":"journal-article","created":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T06:20:36Z","timestamp":1770790836000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Vanishing Bile Duct Syndrome as an Uncommon Hepatic Paraneoplastic Syndrome in Hodgkin\u2019s Lymphoma"],"prefix":"10.1155","volume":"2026","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-5433-3138","authenticated-orcid":false,"given":"Natasha","family":"Salman","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-4777-8868","authenticated-orcid":false,"given":"Diana Sittirat","family":"Petchpailin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-4217-4782","authenticated-orcid":false,"given":"Amanda","family":"Seemann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7336-8787","authenticated-orcid":false,"given":"Apurva","family":"Modi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rohan","family":"Gupta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-8021-844X","authenticated-orcid":false,"given":"Shovendra","family":"Gautam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,2,10]]},"reference":[{"key":"e_1_2_9_1_2","doi-asserted-by":"publisher","DOI":"10.1080\/02841860701644078"},{"key":"e_1_2_9_2_2","unstructured":"Bethesda (MD): National Institute of Diabetes and Digestive and Kidney Diseases; 2012-Vanishing Bile Duct Syndrome LiverTox: Clinical and Research Information on Drug-Induced Liver Injury"},{"key":"e_1_2_9_3_2","doi-asserted-by":"publisher","DOI":"10.4103\/1319-3767.121037"},{"key":"e_1_2_9_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.clml.2024.06.697"},{"key":"e_1_2_9_5_2","doi-asserted-by":"publisher","DOI":"10.3390\/jcm11123253"},{"key":"e_1_2_9_6_2","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v23.i2.366"},{"key":"e_1_2_9_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.29040"},{"key":"e_1_2_9_8_2","doi-asserted-by":"publisher","DOI":"10.1007\/s005340170002"},{"key":"e_1_2_9_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.aohep.2019.06.010"},{"key":"e_1_2_9_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(61)90067-5"},{"key":"e_1_2_9_11_2","volume-title":"Precision Radiation Oncology Volume 5. 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