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Acute infectious causes were ruled out, and elevated inflammatory markers suggested inflammatory diarrhea or autoimmune conditions. Esophagogastroduodenoscopy (EGD) and colonoscopy were negative. Further testing showed positive antinuclear antibodies (ANAs), ribonucleoprotein (RNP), rheumatoid factor (RF), and hepatitis C virus (HCV) RNA, suggesting an HCV\u2010associated autoimmune process. Hematuria and neuropathic pain raised suspicion for mixed cryoglobulinemia secondary to HCV, supported by low complement levels. Treatment started with prednisone. Cryoglobulins came back positive, confirming mixed cryoglobulinemia secondary to HCV. The patient was referred to the hepatology clinic for antiviral treatment, where he completed treatment, with symptoms resolving, except for his neuropathy.<\/jats:p>","DOI":"10.1155\/crhe\/8382433","type":"journal-article","created":{"date-parts":[[2025,7,24]],"date-time":"2025-07-24T09:51:12Z","timestamp":1753350672000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Unmasking Cryoglobulinemia: A Cold\u2010Blooded Complication of Hepatitis C"],"prefix":"10.1155","volume":"2025","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6654-3273","authenticated-orcid":false,"given":"Alexandra M.","family":"Arges","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-4919-7390","authenticated-orcid":false,"given":"Ari","family":"Levine","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,7,24]]},"reference":[{"key":"e_1_2_11_1_2","doi-asserted-by":"publisher","DOI":"10.3350\/cmh.2022.0349"},{"key":"e_1_2_11_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra2033539"},{"key":"e_1_2_11_3_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra2111003"},{"key":"e_1_2_11_4_2","volume-title":"StatPearls, Treasure Island (FL)","author":"Bhandari J.","year":"2024"},{"key":"e_1_2_11_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinre.2020.11.005"},{"key":"e_1_2_11_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD010404.pub2"}],"container-title":["Case Reports in Hepatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/crhe\/8382433","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1155\/crhe\/8382433","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/crhe\/8382433","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T11:33:30Z","timestamp":1772969610000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/crhe\/8382433"}},"subtitle":[],"editor":[{"given":"Ned","family":"Snyder","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2025,1]]},"references-count":6,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,1]]}},"alternative-id":["10.1155\/crhe\/8382433"],"URL":"https:\/\/doi.org\/10.1155\/crhe\/8382433","archive":["Portico"],"relation":{},"ISSN":["2090-6587","2090-6595"],"issn-type":[{"value":"2090-6587","type":"print"},{"value":"2090-6595","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1]]},"assertion":[{"value":"2025-04-24","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-06-21","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-07-24","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"8382433"}}