{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T15:54:17Z","timestamp":1792598057699,"version":"4.5.0"},"reference-count":14,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T00:00:00Z","timestamp":1792540800000},"content-version":"vor","delay-in-days":293,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Case Reports in Anesthesiology"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:p>A 20\u2010year\u2010old female with asthma, Ehlers\u2013Danlos syndrome, Hashimoto\u2019s thyroiditis, mast cell activation syndrome, and complex regional pain syndrome Type 1 (CRPS1) presented for left transfemoral amputation with osseointegration and nerve reconstruction. To limit CRPS1 exacerbation, neuraxial anesthesia with femoral and sciatic blocks was administered for analgesia. Given the reported history of convulsions following ketamine and propofol, sedation with midazolam, dexmedetomidine, and fentanyl was used. On POD 1, fascia iliaca and sciatic blocks were repeated to mitigate postoperative pain. There were no intraoperative or postoperative complications. With limited literature on anesthesia for osseointegration, this novel case highlights individualized planning, in the setting of adverse responses to anesthetic medications and challenging pain management.<\/jats:p>","DOI":"10.1155\/cria\/6532945","type":"journal-article","created":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T15:15:11Z","timestamp":1792595711000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Anesthesia Considerations for Transfemoral Osseointegration in a Patient With CRPS, Propofol, and Ketamine Allergies: A Case Report"],"prefix":"10.1155","volume":"2026","author":[{"given":"Jake D.","family":"Fanizza","sequence":"first","affiliation":[{"name":"College of Medicine Drexel University  Philadelphia Pennsylvania USA  drexel.edu"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7065-0656","authenticated-orcid":false,"given":"Jason Shih","family":"Hoellwarth","sequence":"additional","affiliation":[{"name":"Osseointegration Limb Replacement Center Hospital for Special Surgery  New York New York USA  hss.edu"},{"name":"Department of Anesthesiology Weill Cornell Medical College  New York New York USA  cornell.edu"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4139-6702","authenticated-orcid":false,"given":"Uchenna O.","family":"Umeh","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology Weill Cornell Medical College  New York New York USA  cornell.edu"},{"name":"Department of Anesthesiology, Critical Care and Pain Management Hospital for Special Surgery  New York New York USA  hss.edu"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,21]]},"reference":[{"key":"e_1_2_8_1_2","doi-asserted-by":"publisher","DOI":"10.1093\/pm\/pnac046"},{"key":"e_1_2_8_2_2","doi-asserted-by":"publisher","DOI":"10.1302\/2058-5241.4.190008"},{"key":"e_1_2_8_3_2","doi-asserted-by":"publisher","DOI":"10.2106\/JBJS.RVW.19.00043"},{"key":"e_1_2_8_4_2","doi-asserted-by":"publisher","DOI":"10.1155\/2022\/7960559"},{"key":"e_1_2_8_5_2","doi-asserted-by":"publisher","DOI":"10.2106\/JBJS.CC.20.00267"},{"key":"e_1_2_8_6_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12893-023-02138-9"},{"key":"e_1_2_8_7_2","doi-asserted-by":"publisher","DOI":"10.1093\/milmed\/usae320"},{"key":"e_1_2_8_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2022.10.005"},{"key":"e_1_2_8_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(11)70106-5"},{"key":"e_1_2_8_10_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcp2415752"},{"key":"e_1_2_8_11_2","doi-asserted-by":"publisher","DOI":"10.1053\/jhsu.2000.18496"},{"key":"e_1_2_8_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jss.2018.03.040"},{"key":"e_1_2_8_13_2","doi-asserted-by":"publisher","DOI":"10.4103\/0970-9185.142857"},{"key":"e_1_2_8_14_2","doi-asserted-by":"publisher","DOI":"10.1213\/ANE.0000000000003315"}],"container-title":["Case Reports in Anesthesiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/cria\/6532945","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1155\/cria\/6532945","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/cria\/6532945","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T15:15:12Z","timestamp":1792595712000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/cria\/6532945"}},"subtitle":[],"editor":[{"given":"Anjan","family":"Trikha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":14,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["10.1155\/cria\/6532945"],"URL":"https:\/\/doi.org\/10.1155\/cria\/6532945","archive":["Portico"],"relation":{},"ISSN":["2090-6382","2090-6390"],"issn-type":[{"value":"2090-6382","type":"print"},{"value":"2090-6390","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"2026-04-28","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-10-07","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-10-21","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"6532945"}}