{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T13:49:49Z","timestamp":1790603389615,"version":"4.1.0"},"reference-count":14,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,9,29]],"date-time":"2025-09-29T00:00:00Z","timestamp":1759104000000},"content-version":"vor","delay-in-days":271,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Case Reports in Anesthesiology"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:p>Charcot\u2013Marie\u2013Tooth (CMT) is a hereditary neuromuscular syndrome associated with peripheral neuropathy. We describe a case of long\u2010standing CMT disease who underwent general anesthesia for a total knee replacement and developed significant perioperative hypotension. Clinical assessment revealed vasoplegia due to underlying autonomic dysfunction as the most likely cause. Further review also revealed a similar episode of intraoperative hypotension during a previous anesthetic. After failure of conservative strategies, the patient was started on a vasopressor infusion. However, hypotension persisted in the early postoperative period. This case serves to highlight the significance of autonomic dysfunction in CMT patients which can cause perioperative hypotension, a finding that has been rarely reported in the literature. We also discuss current diagnostic modalities that may be useful in managing cases of autonomic dysfunction that may present with hypotension.<\/jats:p>","DOI":"10.1155\/cria\/9639101","type":"journal-article","created":{"date-parts":[[2025,9,29]],"date-time":"2025-09-29T21:03:33Z","timestamp":1759179813000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Charcot\u2013Marie\u2013Tooth Disease With Persistent Perioperative Hypotension due to Autonomic Dysfunction: A Case Report"],"prefix":"10.1155","volume":"2025","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7406-0063","authenticated-orcid":false,"given":"Keevan","family":"Singh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-4993-386X","authenticated-orcid":false,"given":"Anna-Maria","family":"Lawrence","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,9,29]]},"reference":[{"key":"e_1_2_9_1_2","doi-asserted-by":"publisher","DOI":"10.1093\/bjaceaccp\/mkr019"},{"key":"e_1_2_9_2_2","doi-asserted-by":"publisher","DOI":"10.17085\/apm.23111"},{"key":"e_1_2_9_3_2","unstructured":"Dysautonomia: Perioperative Implications: PMC N.D 2025 https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC3296831\/."},{"key":"e_1_2_9_4_2","doi-asserted-by":"publisher","DOI":"10.1213\/XAA.0000000000001722"},{"key":"e_1_2_9_5_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-198904000-00006"},{"key":"e_1_2_9_6_2","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.26.6.1895"},{"key":"e_1_2_9_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/s1388-2457(03)00159-7"},{"key":"e_1_2_9_8_2","doi-asserted-by":"publisher","DOI":"10.3329\/bsmmuj.v17i2.71958"},{"key":"e_1_2_9_9_2","doi-asserted-by":"publisher","DOI":"10.1186\/s44158-022-00045-8"},{"key":"e_1_2_9_10_2","doi-asserted-by":"publisher","DOI":"10.1177\/10892532231165088"},{"key":"e_1_2_9_11_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-019-05618-w"},{"key":"e_1_2_9_12_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13089-022-00286-2"},{"key":"e_1_2_9_13_2","doi-asserted-by":"publisher","DOI":"10.7863\/ultra.15.14.08059"},{"key":"e_1_2_9_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.accpm.2021.100964"}],"container-title":["Case Reports in Anesthesiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/cria\/9639101","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1155\/cria\/9639101","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/cria\/9639101","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T11:56:54Z","timestamp":1772971014000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/cria\/9639101"}},"subtitle":[],"editor":[{"given":"Srijoni","family":"Sengupta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2025,1]]},"references-count":14,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,1]]}},"alternative-id":["10.1155\/cria\/9639101"],"URL":"https:\/\/doi.org\/10.1155\/cria\/9639101","archive":["Portico"],"relation":{},"ISSN":["2090-6382","2090-6390"],"issn-type":[{"value":"2090-6382","type":"print"},{"value":"2090-6390","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1]]},"assertion":[{"value":"2025-02-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-09-11","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-09-29","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"9639101"}}