{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T15:23:52Z","timestamp":1791559432251,"version":"4.3.4"},"reference-count":8,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"vor","delay-in-days":243,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Case Reports in Cardiology"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:p>Ponatinib is a third\u2010generation BCR:ABL1 tyrosine kinase inhibitor used in selected patients with Philadelphia chromosome\u2010positive acute lymphoblastic leukemia (Ph+\u2009ALL), particularly those with T315I mutations, or disease resistant, or those intolerant to prior tyrosine kinase inhibitors. Although effective, ponatinib has been associated with arterial occlusive events. We report a 63\u2010year\u2010old man with Ph+\u2009ALL who, while receving ponatinib, developed a myocardial infarction requiring quadruple coronary artery bypass grafting, followed by symptomatic intracranial arterial stenosis necessitating superficial temporal artery to middle cerebral artery bypass. Despite multiple cardiovascular risk factors, the chronology of progressive coronary and cerebral vascular disease raised suspicion for ponatinib\u2010associated vasculopathy, although causality cannot be established. To our knowledge, this is the first reported case of sequential coronary and cerebral surgical revascularization occurring during ponatinib therapy. This case highlights the importance of careful cardiovascular surveillance, multidisciplinary management, and individualized risk\u2010benefit assessment in patients treated with ponatinib.<\/jats:p>","DOI":"10.1155\/cric\/3296809","type":"journal-article","created":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T15:07:41Z","timestamp":1788275261000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Cardiovascular and Cerebrovascular Complications Following Ponatinib for Philadelphia Chromosome\u2010Positive Acute Lymphoblastic Leukemia"],"prefix":"10.1155","volume":"2026","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3020-2346","authenticated-orcid":false,"given":"Catherine","family":"Boldig","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-9226-3927","authenticated-orcid":false,"given":"Andrew","family":"Herson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-8281-7141","authenticated-orcid":false,"given":"Justin","family":"Falk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-4696-3705","authenticated-orcid":false,"given":"Mitchell","family":"Boshkos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9449-6494","authenticated-orcid":false,"given":"David Z.","family":"Rose","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,1]]},"reference":[{"key":"e_1_2_10_1_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13045-021-01221-z"},{"key":"e_1_2_10_2_2","unstructured":"NetworkN. C. C. Acute Lymphoblastic Leukemia Version 1.2026 NCCN Clinical Practice Guidelines in Oncology 2026 https:\/\/www.nccn.org\/professionals\/physician_gls\/pdf\/all.pdf."},{"key":"e_1_2_10_3_2","doi-asserted-by":"publisher","DOI":"10.3390\/cancers14071805"},{"key":"e_1_2_10_4_2","doi-asserted-by":"publisher","DOI":"10.1159\/000501927"},{"key":"e_1_2_10_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2020.05.077"},{"key":"e_1_2_10_6_2","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2019000268"},{"key":"e_1_2_10_7_2","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2018025874"},{"key":"e_1_2_10_8_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21186556"}],"container-title":["Case Reports in Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/cric\/3296809","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1155\/cric\/3296809","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/cric\/3296809","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T15:07:43Z","timestamp":1788275263000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/cric\/3296809"}},"subtitle":[],"editor":[{"given":"Satabdi","family":"Datta Choudhury","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":8,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["10.1155\/cric\/3296809"],"URL":"https:\/\/doi.org\/10.1155\/cric\/3296809","archive":["Portico"],"relation":{},"ISSN":["2090-6404","2090-6412"],"issn-type":[{"value":"2090-6404","type":"print"},{"value":"2090-6412","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"2025-06-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-12","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-01","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"3296809"}}