{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T08:13:00Z","timestamp":1775549580396,"version":"3.50.1"},"reference-count":15,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T00:00:00Z","timestamp":1775520000000},"content-version":"vor","delay-in-days":96,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Case Reports in Cardiology"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Ventricular tachycardia (VT) may represent the first manifestation of inherited cardiomyopathies, particularly in young patients without overt structural heart disease. Arrhythmogenic cardiomyopathy (ACM) is an inherited myocardial disorder characterized by ventricular arrhythmias, fibrofatty myocardial replacement, and an increased risk of sudden cardiac death. Pathogenic variants in the desmoplakin (DSP) gene have been increasingly associated with left\u2010dominant or biventricular forms of ACM and inflammatory \u201chot phases\u201d of myocardial injury.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case Presentation<\/jats:title>\n                    <jats:p>\n                      We report the case of a 37\u2010year\u2010old male presenting with sustained monomorphic VT with right ventricular outflow tract morphology requiring synchronized electrical cardioversion. Electrocardiography in sinus rhythm demonstrated low\u2010voltage limb leads and T\u2010wave inversion in V1\u2013V3. Echocardiography showed mildly reduced right ventricular function with dyskinesia of the RV free wall (TAPSE 17\u2009mm, RV S\u2009\n                      <jats:sup>\u2032<\/jats:sup>\n                      10\u2009cm\/s). Cardiac magnetic resonance revealed mild RV dilation and subepicardial late gadolinium enhancement in the lateral left ventricular wall with mild pericardial involvement, consistent with an ACM\u2010related inflammatory phenotype. An implantable cardioverter defibrillator was implanted for secondary prevention. Genetic testing identified a heterozygous pathogenic DSP frameshift variant (c.1009_1010dup; p.Leu338Serfs36\u2217), confirming the diagnosis of DSP\u2010related ACM.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This case highlights the importance of integrating electrocardiography, multimodality imaging, and genetic testing in the evaluation of VT in young adults. Identification of a pathogenic DSP variant confirmed the diagnosis of ACM and has important implications for arrhythmic risk stratification and family screening.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1155\/cric\/5899286","type":"journal-article","created":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T07:33:32Z","timestamp":1775547212000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Recurrent Ventricular Tachycardia in a Young Adult\u2014Imaging and Genetic Evidence of\n                    <i>DSP<\/i>\n                    \u2010Associated Arrhythmogenic Cardiomyopathy: A Case Report"],"prefix":"10.1155","volume":"2026","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9627-7028","authenticated-orcid":false,"given":"Luis Enrique","family":"Gomez","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-5082-2745","authenticated-orcid":false,"given":"Nicolas","family":"Martinenghi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7453-7896","authenticated-orcid":false,"given":"Martin","family":"Ortiz-Genga","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0626-7657","authenticated-orcid":false,"given":"Mercedes Saenz","family":"Tejeira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2985-4790","authenticated-orcid":false,"given":"Paula","family":"Buonfiglio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-6177-7894","authenticated-orcid":false,"given":"Andres Nicolas","family":"Atama\u00f1uk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,4,7]]},"reference":[{"key":"e_1_2_14_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(82)90443-X"},{"key":"e_1_2_14_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccep.2017.08.004"},{"key":"e_1_2_14_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2020.03.019"},{"key":"e_1_2_14_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/pace.12064"},{"key":"e_1_2_14_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehac262"},{"key":"e_1_2_14_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2019.04.002"},{"key":"e_1_2_14_7_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.68.5.917"},{"key":"e_1_2_14_8_2","doi-asserted-by":"publisher","DOI":"10.1272\/jnms.2018_85-14"},{"key":"e_1_2_14_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2009.06.017"},{"key":"e_1_2_14_10_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198801213180301"},{"key":"e_1_2_14_11_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1509267"},{"key":"e_1_2_14_12_2","doi-asserted-by":"publisher","DOI":"10.1161\/circgen.120.003273"},{"key":"e_1_2_14_13_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehaa141"},{"key":"e_1_2_14_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2020.06.005"},{"key":"e_1_2_14_15_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCGEN.121.003672"}],"container-title":["Case 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