{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T15:22:58Z","timestamp":1791559378027,"version":"4.3.4"},"reference-count":14,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T00:00:00Z","timestamp":1787097600000},"content-version":"vor","delay-in-days":230,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Case Reports in Cardiology"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Type II heparin\u2010induced thrombocytopenia (HIT) is a catastrophic immunothrombotic disorder that can be triggered by minimal heparin exposure during routine coronary angiography.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case Summary<\/jats:title>\n                    <jats:p>A 67\u2010year\u2010old woman developed \u201cexplosive\u201d multiterritorial arterial thrombosis\u2014including acute limb ischemia, an inferior STEMI, and a stroke\u2014within minutes of receiving 5000 units of intra\u2010arterial heparin. This followed a brief nadroparin exposure 8 days prior. Crucially, events occurred while platelet counts were still normal. Despite a negative functional assay, a high 4T score (6 points) confirmed HIT. Management involved non\u2010heparin anticoagulation (danaparoid sodium) and thrombectomies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>This case highlights a major diagnostic pitfall: severe arterial thrombosis preceding overt thrombocytopenia. The immediate \u201canaphylactoid\u2010like\u201d reaction following a heparin bolus is often misidentified as contrast allergy, delaying life\u2010saving intervention.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Take Home Messages<\/jats:title>\n                    <jats:p>Suspect HIT in acute systemic reactions or multifocal thrombosis after heparin exposure, regardless of initial platelet counts.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1155\/cric\/6999917","type":"journal-article","created":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T12:03:28Z","timestamp":1787141008000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Explosive Multiterritorial Arterial Thrombosis Following Brief Heparin Exposure: A Diagnostic Pitfall in the Cath Lab"],"prefix":"10.1155","volume":"2026","author":[{"given":"Justine","family":"Massart","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1583-5882","authenticated-orcid":false,"given":"Claudiu","family":"Ungureanu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yves","family":"Dascotte","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacques","family":"Auslender","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-0880-0491","authenticated-orcid":false,"given":"Adrien","family":"Jossart","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,19]]},"reference":[{"key":"e_1_2_11_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsha.2011.07.003"},{"key":"e_1_2_11_2_2","doi-asserted-by":"publisher","DOI":"10.5539\/gjhs.v4n1p65"},{"key":"e_1_2_11_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2016.02.073"},{"key":"e_1_2_11_4_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1538-7836.2003.00270.x"},{"key":"e_1_2_11_5_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.seminhematol.2022.02.005"},{"key":"e_1_2_11_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.19663"},{"key":"e_1_2_11_7_2","doi-asserted-by":"publisher","DOI":"10.2147\/IJGM.S420327"},{"key":"e_1_2_11_8_2","doi-asserted-by":"publisher","DOI":"10.3390\/jcm13164686"},{"key":"e_1_2_11_9_2","doi-asserted-by":"publisher","DOI":"10.1177\/1358863X19898253"},{"key":"e_1_2_11_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.rpth.2026.103373"},{"key":"e_1_2_11_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.24006"},{"key":"e_1_2_11_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/jth.13516"},{"key":"e_1_2_11_13_2","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics13183019"},{"key":"e_1_2_11_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/ccr3.3448"}],"container-title":["Case Reports in Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/cric\/6999917","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1155\/cric\/6999917","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/cric\/6999917","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T12:03:29Z","timestamp":1787141009000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/cric\/6999917"}},"subtitle":[],"editor":[{"given":"Satabdi","family":"Datta Choudhury","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":14,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["10.1155\/cric\/6999917"],"URL":"https:\/\/doi.org\/10.1155\/cric\/6999917","archive":["Portico"],"relation":{},"ISSN":["2090-6404","2090-6412"],"issn-type":[{"value":"2090-6404","type":"print"},{"value":"2090-6412","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"2026-03-31","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-27","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-19","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"6999917"}}