{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T09:26:35Z","timestamp":1773048395261,"version":"3.50.1"},"reference-count":12,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T00:00:00Z","timestamp":1773014400000},"content-version":"vor","delay-in-days":67,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Case Reports in Cardiology"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:p>Infective endocarditis (IE) imposes a challenge in clinical practice, often demanding rapid and precise identification of the causative agent to guide tailored therapeutic interventions. However, a subset of cases presents an elusive diagnostic dilemma with culture\u2010negative results, thereby complicating the management strategy. This case report sheds light on a particularly rare instance of culture\u2010negative IE in a 21\u2010year\u2010old previously healthy male who presented with dyspnea and jaundice, emphasizing the scarcity of such cases in the existing medical literature. Through a detailed examination of clinical manifestations, diagnostic modalities, and treatment outcomes, we aim to contribute valuable insights into the nuanced aspects of culture\u2010negative IE. Furthermore, this report underscores the imperative need for clinicians to maintain a high index of suspicion for IE, even in the absence of positive cultures, to ensure timely and appropriate management for improved patient prognosis.<\/jats:p>","DOI":"10.1155\/cric\/7676322","type":"journal-article","created":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T08:24:45Z","timestamp":1773044685000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Culture\u2010Negative Infective Endocarditis Presenting With Cardio\u2010Hepatorenal Syndrome in a 21\u2010Year\u2010Old Patient: A Case Report of Diagnostic Workup and Management"],"prefix":"10.1155","volume":"2026","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7740-392X","authenticated-orcid":false,"given":"Jana","family":"Kotaich","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-0702-1144","authenticated-orcid":false,"given":"Safaa","family":"Ghanem","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2477-4583","authenticated-orcid":false,"given":"Nour","family":"Mina","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6446-3192","authenticated-orcid":false,"given":"Rayyan","family":"El Saleh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6133-597X","authenticated-orcid":false,"given":"Rim","family":"Awada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Said","family":"Chaaban","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karim","family":"Jammal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,3,9]]},"reference":[{"key":"e_1_2_11_1_2","doi-asserted-by":"publisher","DOI":"10.7861\/clinmed.cme.20.1.1"},{"key":"e_1_2_11_2_2","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000008392"},{"key":"e_1_2_11_3_2","doi-asserted-by":"publisher","DOI":"10.1136\/heartjnl-2015-308791"},{"key":"e_1_2_11_4_2","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.14.1.177-207.2001"},{"key":"e_1_2_11_5_2","doi-asserted-by":"publisher","DOI":"10.1086\/653675"},{"key":"e_1_2_11_6_2","doi-asserted-by":"publisher","DOI":"10.2174\/1871529x10909040240"},{"key":"e_1_2_11_7_2","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1177\/000331979004101101","article-title":"Cardiogenic Hepatorenal Syndrome","volume":"41","author":"Naschitz J. 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