{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T14:26:44Z","timestamp":1786631204476,"version":"build-2736575974"},"reference-count":17,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T00:00:00Z","timestamp":1786579200000},"content-version":"vor","delay-in-days":224,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Case Reports in Dentistry"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:p>This report describes a rare case of unicentric Castleman disease (UCD) involving the submandibular gland and lymph nodes. A 56\u2010year\u2010old man presented with an asymptomatic, slowly growing left submandibular mass. Imaging revealed well\u2010defined heterogeneous structures with prominent vascularity. Excisional biopsy of the gland and adjacent lymph nodes was performed. Histopathological examination showed features characteristic of the hyaline\u2010vascular variant of Castleman disease, including atrophic germinal centers with concentric \u201conion\u2010skin\u201d layering and prominent vascularity, confirmed by immunohistochemistry. No systemic involvement was found. These findings confirmed the unicentric subtype. After complete surgical excision and 3 years of follow\u2010up, the patient remained disease\u2010free. This report underscores that UCD can occur in the submandibular region, should be included in the differential diagnosis of submandibular masses, diagnosed by characteristic imaging (well\u2010defined heterogeneous structures with prominent vascularity) and histopathology (hyaline\u2010vascular variant), and cured by complete surgical resection.<\/jats:p>","DOI":"10.1155\/crid\/2704215","type":"journal-article","created":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T13:26:42Z","timestamp":1786627602000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Unicentric Castleman Disease Involving the Submandibular Gland: A Case Report"],"prefix":"10.1155","volume":"2026","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-9373-2134","authenticated-orcid":false,"given":"Xinlong","family":"Sun","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-1155-4039","authenticated-orcid":false,"given":"Pengfei","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-7237-6847","authenticated-orcid":false,"given":"Beining","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-1828-3938","authenticated-orcid":false,"given":"Linkai","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-1447-002X","authenticated-orcid":false,"given":"Legang","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5024-3153","authenticated-orcid":false,"given":"Yuliang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,13]]},"reference":[{"key":"e_1_2_11_1_2","doi-asserted-by":"publisher","DOI":"10.3760\/cma.j.cn112144-20220810-00443"},{"key":"e_1_2_11_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-023-08110-w"},{"key":"e_1_2_11_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12105-022-01420-1"},{"key":"e_1_2_11_4_2","doi-asserted-by":"publisher","DOI":"10.1177\/014556131709600320"},{"key":"e_1_2_11_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.lanwpc.2023.100720"},{"key":"e_1_2_11_6_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13256-024-04468-5"},{"key":"e_1_2_11_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.joms.2019.11.008"},{"key":"e_1_2_11_8_2","first-page":"399","article-title":"Uni-Centric Localization of Castleman\u2032s Disease Treated With Laparoscopic and Traditional Approach. 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