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The major risk factor for the precipitation of MRONJ in a patient taking antiresorptive medication is dentoalveolar trauma such as dental extractions. Management of MRONJ in oncology patients is exceptionally challenging. In this report, two multiple myeloma patients with longstanding advanced\u2010stage MRONJ were successfully managed with combined pentoxifylline\u2013tocopherol treatment pre\u2010 and postextraction\/sequestrectomy. In conclusion, based on this report and other published reports, it appears that the use of combined pentoxifylline\u2013tocopherol protocol in the management of MRONJ is effective.<\/jats:p>","DOI":"10.1155\/crid\/2765925","type":"journal-article","created":{"date-parts":[[2025,5,8]],"date-time":"2025-05-08T00:54:28Z","timestamp":1746665668000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Management of Medication\u2010Related Osteonecrosis of the Jaw in Multiple Myeloma Patients With Pentoxifylline and Tocopherol: Case Reports"],"prefix":"10.1155","volume":"2025","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-8290-6723","authenticated-orcid":false,"given":"Adepitan A.","family":"Owosho","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine 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