{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T04:18:33Z","timestamp":1783570713475,"version":"3.55.0"},"reference-count":39,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T00:00:00Z","timestamp":1783468800000},"content-version":"vor","delay-in-days":188,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Case Reports in Dentistry"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Deep residual periodontal pockets after nonsurgical periodontal therapy represent a clinical challenge, particularly in molar sites with furcation involvement. This case report describes the short\u2010term outcome of a combined conservative retreatment protocol including repeated subgingival instrumentation, erythritol\u2010based air polishing, and adjunctive application of a mucoadhesive polymeric hydrogel.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case Presentation<\/jats:title>\n                    <jats:p>A 57\u2010year\u2010old systemically healthy, nonsmoking female with periodontitis, Stage III Grade B, presented with a persistent 9\u2009mm residual pocket and Grade II buccal furcation involvement at Tooth 26 (maxillary left first molar) after initial nonsurgical periodontal therapy. The patient showed good plaque control and preferred to avoid surgical treatment. The site was retreated with mechanical debridement, subgingival erythritol air polishing, and adjunctive hydrogel application. A second hydrogel application was performed after 37 days because bleeding on probing persisted despite partial pocket reduction.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Outcome<\/jats:title>\n                    <jats:p>At 4 months after the first hydrogel application, probing depth at the treated site decreased from 9 to 3\u2009mm, bleeding on probing was absent, and furcation involvement was clinically reduced from Grade II to Grade I. No adverse events were reported.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In this single highly compliant patient, a combined conservative retreatment protocol was associated with short\u2010term clinical improvement of a deep residual periodontal pocket with furcation involvement. Because multiple interventions were performed and concurrent clear\u2010aligner therapy was present, the specific contribution of the hydrogel cannot be isolated. Longer follow\u2010up and controlled studies are needed before any inference regarding efficacy or equivalence to surgical therapy can be made.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1155\/crid\/3170326","type":"journal-article","created":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T04:11:00Z","timestamp":1783570260000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Conservative Management of Deep Residual Periodontal Pockets Using Adjunctive Mucoadhesive Polymeric Hydrogel: A Case Report With 4\u2010Month Follow\u2010Up"],"prefix":"10.1155","volume":"2026","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6184-6454","authenticated-orcid":false,"given":"Stefano","family":"Sarri","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0353-1184","authenticated-orcid":false,"given":"Scilla","family":"Sparabombe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Riccardo","family":"Scaringi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-3823-2175","authenticated-orcid":false,"given":"Enrico","family":"Fiorini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorenzo","family":"De Marco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8263-4880","authenticated-orcid":false,"given":"Simone","family":"Sevi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,8]]},"reference":[{"key":"e_1_2_14_1_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2017.38"},{"key":"e_1_2_14_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2024.124263"},{"key":"e_1_2_14_3_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-051X.29.s2.4.x"},{"key":"e_1_2_14_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.13245"},{"key":"e_1_2_14_5_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-051X.29.s3.5.x"},{"key":"e_1_2_14_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1998.tb02419.x"},{"key":"e_1_2_14_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2021.03.041"},{"key":"e_1_2_14_8_2","doi-asserted-by":"publisher","DOI":"10.1902\/annals.2003.8.1.79"},{"key":"e_1_2_14_9_2","doi-asserted-by":"publisher","DOI":"10.1039\/D3TB03070A"},{"key":"e_1_2_14_10_2","doi-asserted-by":"publisher","DOI":"10.3389\/fbioe.2024.1380528"},{"key":"e_1_2_14_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0939-6411(00)00090-4"},{"key":"e_1_2_14_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/mabi.201000388"},{"key":"e_1_2_14_13_2","doi-asserted-by":"publisher","DOI":"10.1155\/2024\/3113479"},{"key":"e_1_2_14_14_2","doi-asserted-by":"publisher","DOI":"10.56609\/jac.v41i1.269"},{"key":"e_1_2_14_15_2","unstructured":"Sterify Gel Technical Documentation Clinical Investigation Report: Microbiological Evaluation of Mucoadhesive Polymeric Hydrogel as Adjunct to Scaling and Root Planing 2024 Sterify Srl Italy; Hu-Friedy Mfg. Co. LLC."},{"key":"e_1_2_14_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/JPER.18-0006"},{"key":"e_1_2_14_17_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1975.tb01734.x"},{"key":"e_1_2_14_18_2","doi-asserted-by":"publisher","DOI":"10.1038\/nri3785"},{"key":"e_1_2_14_19_2","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines10102651"},{"key":"e_1_2_14_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jare.2017.01.005"},{"key":"e_1_2_14_21_2","doi-asserted-by":"publisher","DOI":"10.4103\/0110-5558.76436"},{"key":"e_1_2_14_22_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrd2004"},{"key":"e_1_2_14_23_2","doi-asserted-by":"crossref","DOI":"10.1128\/AEM.00052-18","article-title":"Increasing the Antimicrobial Activity of Nisin-Based Lantibiotics Against Gram-Negative Pathogens","volume":"84","author":"Li Q.","year":"2018","journal-title":"Applied and Environmental Microbiology"},{"key":"e_1_2_14_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbiotec.2019.12.016"},{"key":"e_1_2_14_25_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12967-014-0219-9"},{"key":"e_1_2_14_26_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00210-009-0399-7"},{"key":"e_1_2_14_27_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00210-005-1078-y"},{"key":"e_1_2_14_28_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0765.2011.01430.x"},{"key":"e_1_2_14_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2012.11.110"},{"key":"e_1_2_14_30_2","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.13259"},{"key":"e_1_2_14_31_2","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1111\/prd.12048","article-title":"Clinical Concepts for Regenerative Therapy in Intrabony Defects","volume":"68","author":"Cortellini P.","year":"2015","journal-title":"Periodontology 2000"},{"key":"e_1_2_14_32_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2008.01257.x"},{"key":"e_1_2_14_33_2","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12026"},{"key":"e_1_2_14_34_2","doi-asserted-by":"publisher","DOI":"10.1177\/08959374980120010501"},{"key":"e_1_2_14_35_2","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1111\/j.1600-0757.2010.00346.x","article-title":"Photodynamic Therapy in the Control of Oral Biofilms","volume":"55","author":"Soukos N. S.","year":"2011","journal-title":"Periodontology 2000"},{"key":"e_1_2_14_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdent.2016.03.002"},{"key":"e_1_2_14_37_2","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2003.74.3.391"},{"key":"e_1_2_14_38_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-134-4-200102200-00017"},{"key":"e_1_2_14_39_2","volume-title":"Clinical Case Reporting in Evidence-Based Medicine","author":"Jenicek M.","year":"2001"}],"container-title":["Case Reports in Dentistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/crid\/3170326","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1155\/crid\/3170326","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/crid\/3170326","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T04:11:02Z","timestamp":1783570262000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/crid\/3170326"}},"subtitle":[],"editor":[{"given":"Hannah","family":"Wesley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":39,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["10.1155\/crid\/3170326"],"URL":"https:\/\/doi.org\/10.1155\/crid\/3170326","archive":["Portico"],"relation":{},"ISSN":["2090-6447","2090-6455"],"issn-type":[{"value":"2090-6447","type":"print"},{"value":"2090-6455","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"2026-04-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-25","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-08","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"3170326"}}