{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,18]],"date-time":"2026-07-18T11:03:58Z","timestamp":1784372638710,"version":"3.55.0"},"reference-count":21,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,7,18]],"date-time":"2026-07-18T00:00:00Z","timestamp":1784332800000},"content-version":"vor","delay-in-days":198,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Case Reports in Dentistry"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background and Aim<\/jats:title>\n                    <jats:p>Fibrous dysplasia (FD) is a benign fibro\u2010osseous condition, characterized by replacement of normal bone with immature fibrous tissue due to GNAS mutations, whereas central giant cell granuloma (CGCG) is a reactive lesion featuring multinucleated giant cells in a vascular stroma. Although some hybrid lesions combining FD and CGCG have been reported as synchronous entities, metachronous occurrences, where FD develops years after CGCG excision, are rare. This report describes a case of metachronous FD arising at the site of a previously excised CGCG after a 10\u2010year interval, exploring potential temporal association and emphasizing the need for extended follow\u2010up.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case Presentation<\/jats:title>\n                    <jats:p>A 50\u2010year\u2010old woman presented with a firm, gradually enlarging swelling in the right maxilla that had developed over 2 years. Her history included surgical excision of a pure CGCG (no fibro\u2010osseous elements) in the same location 10 years prior. Clinical examination revealed bony\u2010hard expansion without neurosensory deficits or lymphadenopathy. Cone\u2010beam computed tomography showed a poorly defined, expansile radiopaque mass with a ground\u2010glass pattern, obliterating the maxillary sinus. An incisional biopsy showed evidence of FD, with irregular woven bone trabeculae in fibrous stroma lacking osteoblastic rimming.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>To the best of our knowledge, this is one of the first reported metachronous cases of FD arising de novo at the site of a previously excised CGCG following a 10\u2010year interval. This report underscores the importance of long\u2010term follow\u2010up for patients with jaw pathologies to detect rare sequential developments.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1155\/crid\/3449150","type":"journal-article","created":{"date-parts":[[2026,7,18]],"date-time":"2026-07-18T10:33:14Z","timestamp":1784370794000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Fibrous Dysplasia Developed at the Site of a Previous Central Giant Cell Granuloma in a Middle\u2010Aged Patient: A Case Report"],"prefix":"10.1155","volume":"2026","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8097-1138","authenticated-orcid":false,"given":"Mahdi","family":"Niknami","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0691-1580","authenticated-orcid":false,"given":"Nazanin","family":"Mahdavi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1581-0159","authenticated-orcid":false,"given":"Zahra","family":"Madani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,18]]},"reference":[{"key":"e_1_2_11_1_2","doi-asserted-by":"publisher","DOI":"10.7181\/acfs.2023.00101"},{"key":"e_1_2_11_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/s13244-018-0666-6"},{"key":"e_1_2_11_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/eye.2009.6"},{"key":"e_1_2_11_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.coms.2012.05.004"},{"key":"e_1_2_11_5_2","doi-asserted-by":"crossref","DOI":"10.1016\/j.jormas.2023.101660","article-title":"Craniofacial Fibrous Dysplasia: Systematic Review of Facial Management","volume":"124","author":"Bouet B.","year":"2023","journal-title":"Journal of Stomatology, Oral and Maxillofacial Surgery"},{"key":"e_1_2_11_6_2","doi-asserted-by":"publisher","DOI":"10.29271\/jcpsp.2018.06.S128"},{"key":"e_1_2_11_7_2","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/170412"},{"key":"e_1_2_11_8_2","doi-asserted-by":"publisher","DOI":"10.22038\/ijorl.2021.53844.2838"},{"key":"e_1_2_11_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2023.e16221"},{"key":"e_1_2_11_10_2","doi-asserted-by":"publisher","DOI":"10.7860\/JCDR\/2013\/5533.2987"},{"key":"e_1_2_11_11_2","doi-asserted-by":"publisher","DOI":"10.1177\/20363613231165883"},{"key":"e_1_2_11_12_2","doi-asserted-by":"publisher","DOI":"10.15517\/pbprpe28"},{"key":"e_1_2_11_13_2","doi-asserted-by":"publisher","DOI":"10.18502\/fid.v18i44.8340"},{"key":"e_1_2_11_14_2","doi-asserted-by":"publisher","DOI":"10.3390\/dj12090295"},{"key":"e_1_2_11_15_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22041568"},{"key":"e_1_2_11_16_2","first-page":"E130","article-title":"Central Giant Cell Granuloma and Fibrous Dysplasia Occurring in the Same Jaw","volume":"10","author":"Farzaneh A. H.","year":"2005","journal-title":"Medicina Oral, Patologia Oral, Cirugia Bucal"},{"key":"e_1_2_11_17_2","doi-asserted-by":"publisher","DOI":"10.1259\/dmfr\/16645318"},{"key":"e_1_2_11_18_2","doi-asserted-by":"publisher","DOI":"10.23937\/2643-3907\/1710053"},{"key":"e_1_2_11_19_2","doi-asserted-by":"publisher","DOI":"10.4103\/0973-029X.174631"},{"key":"e_1_2_11_20_2","volume-title":"A Hybrid Lesion of the Jaw Containing Fibrous Dysplasia and Central Giant Cell Granuloma Components","author":"Rahimov C.","year":"2013"},{"key":"e_1_2_11_21_2","doi-asserted-by":"crossref","DOI":"10.22541\/au.174383477.76309262\/v1","volume-title":"Fibrous Dysplasia Developed at the Site of a Previous Central Giant Cell Granuloma in an Elderly Patient: A Case Report","author":"Niknami M.","year":"2025"}],"container-title":["Case Reports in Dentistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/crid\/3449150","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1155\/crid\/3449150","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/crid\/3449150","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,18]],"date-time":"2026-07-18T10:33:16Z","timestamp":1784370796000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/crid\/3449150"}},"subtitle":[],"editor":[{"given":"Hamoun","family":"Sabri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":21,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["10.1155\/crid\/3449150"],"URL":"https:\/\/doi.org\/10.1155\/crid\/3449150","archive":["Portico"],"relation":{},"ISSN":["2090-6447","2090-6455"],"issn-type":[{"value":"2090-6447","type":"print"},{"value":"2090-6455","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"2025-09-15","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-13","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-18","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"3449150"}}