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It can occur in diseases such as renal fibrosis, atherosclerosis, and oral submucous fibrosis. Homogeneous eosinophilic deposits characterize it. However, the occurrence of hyaline degeneration is rarely accompanied by calcification. We present a rare case of a 33\u2010year\u2010old female patient diagnosed with a calcified nodule of the upper lip mucosa, which was confirmed as a benign entity without malignancy. This report is aimed at enhancing understanding of this condition and providing a reference for future diagnosis and treatment strategies.<\/jats:p>","DOI":"10.1155\/crid\/5553158","type":"journal-article","created":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T05:14:56Z","timestamp":1765602896000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Calcified Hyaline Degeneration Nodule in the Upper Lip Mucosa: A Rare Case Report"],"prefix":"10.1155","volume":"2025","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-3376-4893","authenticated-orcid":false,"given":"Changjun","family":"Huang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-7361-0709","authenticated-orcid":false,"given":"Yujun","family":"Lu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-2367-7129","authenticated-orcid":false,"given":"Kui","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-2720-849X","authenticated-orcid":false,"given":"Fang","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2227-2723","authenticated-orcid":false,"given":"Yajing","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-3801-3807","authenticated-orcid":false,"given":"Yingkun","family":"Luo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,12,12]]},"reference":[{"key":"e_1_2_11_1_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-981-13-8871-2_2"},{"key":"e_1_2_11_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/ccr3.70413"},{"key":"e_1_2_11_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2024.107163"},{"key":"e_1_2_11_4_2","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.47810"},{"key":"e_1_2_11_5_2","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.32237"},{"key":"e_1_2_11_6_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13000-025-01688-1"},{"key":"e_1_2_11_7_2","doi-asserted-by":"publisher","DOI":"10.2209\/tdcpublication.2024-0063"},{"key":"e_1_2_11_8_2","doi-asserted-by":"publisher","DOI":"10.1615\/CritRevImmunol.2018026483"},{"key":"e_1_2_11_9_2","doi-asserted-by":"publisher","DOI":"10.1055\/a-1661-0020"},{"key":"e_1_2_11_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41368-024-00344-6"},{"key":"e_1_2_11_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijporl.2020.110476"},{"key":"e_1_2_11_12_2","volume-title":"StatPearls","author":"Le C.","year":"2023"},{"key":"e_1_2_11_13_2","first-page":"139","article-title":"A Case of Phlebolith in the Tip of Tongue","volume":"48","author":"Kato H.","year":"2023","journal-title":"Tokai Journal of Experimental and Clinical Medicine"},{"key":"e_1_2_11_14_2","first-page":"454","article-title":"Degenerated Subserosal Uterine Leiomyoma Mimicking Carcinoma Ovary","volume":"22","author":"Ranabhat B. 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