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In root\u2010filled teeth, persistent apical periodontitis may be associated with extensive periapical lesions, external inflammatory root resorption affecting the treated or adjacent teeth, and extrusion of endodontic materials. These complications may lead clinicians to consider surgical approaches. However, when canals are adequately cleaned, disinfected, and hermetically obturated, favorable healing may occur following nonsurgical retreatment alone. This case report describes the nonsurgical management of a large periapical lesion associated with a previously treated maxillary lateral incisor. The lesion was complicated by pre\u2010existing sealer extrusion and by external apical inflammatory resorption of the adjacent maxillary central incisor. Repeated calcium hydroxide intracanal medication and obturation were performed, followed by functional coronal restoration. Ongoing radiographic healing and clinical stability were observed at 20 months of follow\u2010up, supporting an orthograde, conservative approach in similar clinical situations.<\/jats:p>","DOI":"10.1155\/crid\/6413120","type":"journal-article","created":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T07:01:36Z","timestamp":1791788496000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Successful Nonsurgical Resolution of a Large Periapical Lesion With Pre\u2010Existing Sealer Extrusion and Adjacent External Inflammatory Root Resorption: A Case Report"],"prefix":"10.1155","volume":"2026","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-9028-6470","authenticated-orcid":false,"given":"Btissam","family":"Seffahi","sequence":"first","affiliation":[{"name":"Department of Conservative Dentistry and Endodontics Faculty of Dental Medicine Mohammed V University  Rabat Morocco  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