{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T19:40:03Z","timestamp":1792352403795,"version":"4.4.0"},"reference-count":30,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T00:00:00Z","timestamp":1792281600000},"content-version":"vor","delay-in-days":290,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Case Reports in Dentistry"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>This study is aimed at describing the oral manifestations and diagnostic pathway of Cowden syndrome in a young patient, highlighting the role of dental professionals in early detection of PTEN\u2010related disorders.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case Presentation<\/jats:title>\n                    <jats:p>A 25\u2010year\u2010old woman presented with long\u2010standing, progressive multifocal oral papillomatous lesions since childhood. Clinical examination revealed macrocephaly and extensive papillomatosis involving the lips, tongue, palate, and buccal mucosa. Histopathological analysis demonstrated verrucous epithelial proliferation with parakeratosis, acanthosis, elongated rete ridges, and low\u2010grade dysplasia. Based on the clinical and histological findings, genetic testing was performed and identified a pathogenic PTEN variant (c.388C&gt;T; p.Arg130Ter), confirming the diagnosis of Cowden syndrome. The patient was subsequently enrolled in a multidisciplinary surveillance program.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Persistent multifocal oral papillomatosis associated with systemic findings should raise suspicion for Cowden syndrome. Early recognition by dental professionals is essential for prompt diagnosis and timely initiation of risk\u2010adapted surveillance strategies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1155\/crid\/7101797","type":"journal-article","created":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T19:03:31Z","timestamp":1792350211000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Oral Manifestations of Cowden Syndrome in a Young Patient: A Case Report With Clinical, Histological, and Genetic Findings"],"prefix":"10.1155","volume":"2026","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4981-5396","authenticated-orcid":false,"given":"Gian Marco","family":"Podda","sequence":"first","affiliation":[{"name":"Department of Oral and Maxillofacial Sciences Sapienza University of Rome  Rome Italy  uniroma1.it"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-4017-4264","authenticated-orcid":false,"given":"Lucia","family":"Borghetti","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Sciences Sapienza University of Rome  Rome Italy  uniroma1.it"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5912-4812","authenticated-orcid":false,"given":"Federica","family":"Rocchetti","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Sciences Sapienza University of Rome  Rome Italy  uniroma1.it"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4913-9471","authenticated-orcid":false,"given":"Niccol\u00f2","family":"Di Giosaffatte","sequence":"additional","affiliation":[{"name":"Laboratory of Medical Genetics Experimental Medicine Department San Camillo-Forlanini Hospital Sapienza University  Rome Italy  uniroma1.it"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0396-7981","authenticated-orcid":false,"given":"Irene","family":"Bottillo","sequence":"additional","affiliation":[{"name":"Laboratory of Medical Genetics Experimental Medicine Department San Camillo-Forlanini Hospital Sapienza University  Rome Italy  uniroma1.it"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6864-2574","authenticated-orcid":false,"given":"Paola","family":"Grammatico","sequence":"additional","affiliation":[{"name":"Laboratory of Medical Genetics Experimental Medicine Department San Camillo-Forlanini Hospital Sapienza University  Rome Italy  uniroma1.it"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4696-0560","authenticated-orcid":false,"given":"Cira Rosaria Tiziana","family":"Di Gioia","sequence":"additional","affiliation":[{"name":"Department of Radiological Oncological and Anatomical Pathology Sciences Sapienza University of Rome  Rome Italy  uniroma1.it"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2439-2187","authenticated-orcid":false,"given":"Umberto","family":"Romeo","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Sciences Sapienza University of Rome  Rome Italy  uniroma1.it"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,18]]},"reference":[{"key":"e_1_2_12_1_2","volume-title":"GeneReviews","author":"Yehia L.","year":"1993"},{"key":"e_1_2_12_2_2","doi-asserted-by":"publisher","DOI":"10.1097\/GIM.0b013e3181ac9aea"},{"key":"e_1_2_12_3_2","doi-asserted-by":"publisher","DOI":"10.3390\/medicina60050767"},{"key":"e_1_2_12_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng0596-114"},{"key":"e_1_2_12_5_2","volume-title":"StatPearls Treasure Island (FL)","author":"Garofola C.","year":"2025"},{"key":"e_1_2_12_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10689-013-9674-3"},{"key":"e_1_2_12_7_2","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-11-2283"},{"key":"e_1_2_12_8_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djt277"},{"key":"e_1_2_12_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctrv.2010.04.002"},{"key":"e_1_2_12_10_2","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000032572"},{"key":"e_1_2_12_11_2","doi-asserted-by":"publisher","DOI":"10.1136\/bcr-2020-236768"},{"key":"e_1_2_12_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmg.2022.104632"},{"key":"e_1_2_12_13_2","volume-title":"NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines): Genetic\/Familial High-Risk Assessment: Breast, Ovarian, Pancreatic, and Prostate. 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