{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,20]],"date-time":"2026-06-20T20:52:09Z","timestamp":1781988729986,"version":"3.54.5"},"reference-count":16,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T00:00:00Z","timestamp":1776211200000},"content-version":"vor","delay-in-days":104,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Case Reports in Dentistry"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Osteopetrosis is a rare genetic disorder characterized by increased bone density due to defective osteoclast function. Its clinical presentation varies according to subtype, and oral manifestations are frequent, potentially serving as early indicators of the disease. These findings place the pediatric dentist in a key role for early recognition and safe dental management.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case<\/jats:title>\n                    <jats:p>This case report describes the comprehensive dental management of a 7\u2010year\u2010old girl with a history of infantile osteopetrosis treated with hematopoietic stem cell transplantation during early infancy. The patient presented with oligodontia, generalized enamel hypoplasia and hypomineralization, dental hypersensitivity, and altered dental morphology. Management focused on prevention\u2010centered care, including professional prophylaxis, topical fluoride therapy (5% sodium fluoride varnish), home fluoridated toothpaste and mouth rinse use, pit and fissure sealants, selective minimally traumatic extractions with antibiotic prophylaxis, and interceptive orthodontic treatment using slow maxillary expansion with a Bertoni appliance. Monthly follow\u2010up visits were conducted over a 12\u2010month period.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Enamel defects remained stable, dental hypersensitivity decreased, no new carious lesions developed, and no infectious or osteonecrotic complications were observed. Slow maxillary expansion improved arch coordination without adverse effects.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>A conservative, prevention\u2010oriented, and multidisciplinary dental approach can be safely implemented in pediatric patients with osteopetrosis. Early identification, minimally invasive procedures, and close follow\u2010up are essential to reduce complications and improve oral health outcomes and quality of life.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1155\/crid\/7684477","type":"journal-article","created":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T14:59:01Z","timestamp":1776265141000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Pediatric Dental Management of a Patient With Infantile Osteopetrosis in Remission: A Clinical Case Report"],"prefix":"10.1155","volume":"2026","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-6348-2114","authenticated-orcid":false,"given":"Maria Amalia","family":"Cruz-Morera","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7715-4778","authenticated-orcid":false,"given":"Katherine","family":"Molina-Chaves","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2132-0137","authenticated-orcid":false,"given":"Adrian","family":"Gomez-Fernandez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,4,15]]},"reference":[{"key":"e_1_2_11_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2022.116615"},{"key":"e_1_2_11_2_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2017-01127"},{"key":"e_1_2_11_3_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms241210412"},{"key":"e_1_2_11_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(77)80441-1"},{"key":"e_1_2_11_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/scd.12427"},{"key":"e_1_2_11_6_2","first-page":"53","article-title":"Oligodontia Associated With Osteopetrosis: A Rare Case Report","volume":"78","author":"Vinay C.","year":"2011","journal-title":"Journal of Dentistry for Children"},{"key":"e_1_2_11_7_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra040952"},{"key":"e_1_2_11_8_2","unstructured":"SchulzA. S. MoshousD. andStewardC. G. et al.ESID; EBMT Working Party Inborn Errors Osteopetrosis: Consensus Guidelines for Diagnosis Therapy and Follow-up. Version 3 2015 Ulm (DE) https:\/\/esid.org\/wp-content\/uploads\/2024\/03\/00_OP_Guidelines_V3.pdf."},{"key":"e_1_2_11_9_2","article-title":"Oral Health in Patients With Osteopetrosis: A Literature Review","volume":"7","author":"Hasselby H.","year":"2022","journal-title":"Clinical Surgery"},{"key":"e_1_2_11_10_2","doi-asserted-by":"publisher","DOI":"10.1007\/s40368-016-0251-y"},{"key":"e_1_2_11_11_2","doi-asserted-by":"publisher","DOI":"10.1242\/dmm.048940"},{"key":"e_1_2_11_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bmt.1703416"},{"key":"e_1_2_11_13_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12903-023-03707-3"},{"key":"e_1_2_11_14_2","doi-asserted-by":"publisher","DOI":"10.1136\/bcr-2014-208085"},{"key":"e_1_2_11_15_2","doi-asserted-by":"publisher","DOI":"10.1177\/14653125241264294"},{"key":"e_1_2_11_16_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrendo.2013.137"}],"container-title":["Case Reports in Dentistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/crid\/7684477","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1155\/crid\/7684477","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/crid\/7684477","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,20]],"date-time":"2026-06-20T20:46:14Z","timestamp":1781988374000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/crid\/7684477"}},"subtitle":[],"editor":[{"given":"Hannah","family":"Wesley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":16,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["10.1155\/crid\/7684477"],"URL":"https:\/\/doi.org\/10.1155\/crid\/7684477","archive":["Portico"],"relation":{},"ISSN":["2090-6447","2090-6455"],"issn-type":[{"value":"2090-6447","type":"print"},{"value":"2090-6455","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"2026-01-07","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-24","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-15","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"7684477"}}