{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T16:42:03Z","timestamp":1787503323321,"version":"build-2736575974"},"reference-count":34,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T00:00:00Z","timestamp":1777852800000},"content-version":"vor","delay-in-days":123,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Case Reports in Dentistry"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Trigeminal neuropathic pain (TNP) is a chronic and debilitating condition frequently resistant to conventional pharmacological therapies. Although cannabinoids have emerged as a potential adjunctive treatment, objective clinical documentation of their effects in orofacial neuropathic pain remains limited.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case Reports<\/jats:title>\n                    <jats:p>\n                      We report two female patients with refractory TNP\u2014one post\u2010traumatic and one idiopathic\u2014who experienced insufficient relief despite trials of anticonvulsants, antidepressants, topical agents, and local interventions. Both patients received a balanced tetrahydrocannabinol (THC):cannabidiol (CBD) sublingual formulation (20\u2009mg\/mL each) following a structured titration protocol and were monitored over 8 weeks. Outcomes were assessed using the Douleur Neuropathique 4 Questions (DN4), the visual analog scale (VAS), the World Health Organization Quality of Life\u2010BREF (WHOQOL\u2010Bref), and qualitative sensory testing (QualST). Additionally, three\u2010dimensional facial stereophotogrammetry was employed to objectively quantify areas of hyperfunction and allodynia. Treatment resulted in a marked analgesic response (VAS reduction from 9 to 4 and from 10 to 2), qualitative changes in pain phenotype\u2014from shock\u2010like to predominantly burning\u2014and functional improvement in mastication and oral hygiene. Stereophotogrammetry demonstrated a substantial reduction in sensitized regions, with extraoral hyperfunctional area decreasing from 113.72 to 27.54\u2009cm\n                      <jats:sup>2<\/jats:sup>\n                      and complete resolution of allodynia by week 8. WHOQOL\u2010Bref scores improved in both patients, with physical domain scores increasing from 50.0 to 60.7 and from 25.0 to 39.3, accompanied by gains in psychological well\u2010being. No serious adverse events were recorded.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>These cases illustrate the potential clinical relevance of cannabinoids as an adjunctive approach for refractory TNP and highlight the importance of multidimensional assessment strategies. The findings should be interpreted cautiously given the descriptive nature of case reports; however, they underscore the need for controlled studies to further investigate the efficacy and safety of cannabinoid\u2010based therapies in orofacial neuropathic pain.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1155\/crid\/7752444","type":"journal-article","created":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T10:00:52Z","timestamp":1777888852000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Cannabinoid Therapy for Refractory Trigeminal Neuropathic Pain: Quantification of Somatosensory Alterations (QualST) by 3D Stereophotogrammetry\u2014Two Case Reports"],"prefix":"10.1155","volume":"2026","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0433-2681","authenticated-orcid":false,"given":"Alex Moreira","family":"M\u00e9lo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-3990-7172","authenticated-orcid":false,"given":"Luiz Guilherme","family":"Spadon-Brito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8210-9098","authenticated-orcid":false,"given":"J\u00faia Carrer","family":"Hallak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Glauce Crivelaro","family":"do Nascimento","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4943-1242","authenticated-orcid":false,"given":"Melissa","family":"de Oliveira 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