{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,20]],"date-time":"2026-06-20T20:52:04Z","timestamp":1781988724507,"version":"3.54.5"},"reference-count":27,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T00:00:00Z","timestamp":1770768000000},"content-version":"vor","delay-in-days":41,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","award":["001"],"award-info":[{"award-number":["001"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Case Reports in Dentistry"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:p>Pleomorphic adenoma (PA) is the most common benign neoplasm of the salivary glands, occurring in both major and minor glands, with a predilection for the intraoral palate. Its presentation in the upper lip is rare and, when large, may result in facial deformity, alveolar bone resorption, and tooth displacement, especially in long\u2010standing lesions. Clinically, PA presents as a solid, painless, slow\u2010growing, and well\u2010circumscribed mass, which may cause functional morbidity depending on its size and location. The differential diagnosis includes canalicular adenoma, other benign minor salivary gland neoplasms, mesenchymal tumors (lipoma, fibroma, neurofibroma, schwannoma, and hemangioma), and cystic lesions (mucocele, dermoid cyst, and epidermoid cyst). Distinguishing among these entities requires a detailed clinical evaluation, imaging studies, and histopathological confirmation, often complemented by immunohistochemistry. Complete excisional biopsy with adequate margins remains the treatment of choice, providing an excellent prognosis and reducing the risk of recurrence or malignant transformation. This report describes an uncommon case of large PA of the upper lip, associated with alveolar bone loss and tooth displacement, highlighting the importance of early diagnosis and appropriate surgical management.<\/jats:p>","DOI":"10.1155\/crid\/8865055","type":"journal-article","created":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T15:14:17Z","timestamp":1770822857000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Large Pleomorphic Adenoma of The Upper Lip in a Middle\u2010Aged Woman With Facial Deformity, Tooth Displacement, and Bone Loss: Uncommon Clinical Presentation of a Benign Tumor"],"prefix":"10.1155","volume":"2026","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-5324-2695","authenticated-orcid":false,"given":"Fabiana","family":"da Silva de Oliveira","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7070-5602","authenticated-orcid":false,"given":"Elias Antonio","family":"da Silva Filho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-1830-5693","authenticated-orcid":false,"given":"Marcela Adell","family":"Trench","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8902-8090","authenticated-orcid":false,"given":"Daniele","family":"Heguedusch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7785-6785","authenticated-orcid":false,"given":"F\u00e1bio Daumas","family":"Nunes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3372-6719","authenticated-orcid":false,"given":"Celso Augusto","family":"Lemos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4966-6295","authenticated-orcid":false,"given":"Norberto Nobuo","family":"Sugaya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,2,11]]},"reference":[{"key":"e_1_2_9_1_2","doi-asserted-by":"publisher","DOI":"10.11604\/pamj.2021.38.146.26508"},{"key":"e_1_2_9_2_2","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000018468"},{"key":"e_1_2_9_3_2","doi-asserted-by":"publisher","DOI":"10.12998\/wjcc.v12.i17.3138"},{"key":"e_1_2_9_4_2","doi-asserted-by":"publisher","DOI":"10.18231\/j.jooo.2021.028"},{"key":"e_1_2_9_5_2","doi-asserted-by":"publisher","DOI":"10.4103\/njms.NJMS_55_17"},{"key":"e_1_2_9_6_2","doi-asserted-by":"publisher","DOI":"10.1136\/bcr-2013-008969"},{"key":"e_1_2_9_7_2","doi-asserted-by":"publisher","DOI":"10.21037\/gs-22-308"},{"key":"e_1_2_9_8_2","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.78166"},{"key":"e_1_2_9_9_2","first-page":"342","article-title":"Prognosticators of Excision of Giant Intra-Oral Tumors in a Resource-Challenged Setting: A Case Report","volume":"41","author":"Segun-Busari S.","year":"2024","journal-title":"West African Journal of Medicine"},{"key":"e_1_2_9_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijscr.2022.107729"},{"key":"e_1_2_9_11_2","doi-asserted-by":"publisher","DOI":"10.4103\/0974-2077.91260"},{"key":"e_1_2_9_12_2","doi-asserted-by":"publisher","DOI":"10.4103\/jcrt.jcrt_2259_22"},{"key":"e_1_2_9_13_2","doi-asserted-by":"publisher","DOI":"10.4103\/njms.NJMS_20_17"},{"key":"e_1_2_9_14_2","doi-asserted-by":"publisher","DOI":"10.4314\/ahs.v19i4.50"},{"key":"e_1_2_9_15_2","doi-asserted-by":"publisher","DOI":"10.3390\/jcm11071808"},{"key":"e_1_2_9_16_2","doi-asserted-by":"publisher","DOI":"10.5604\/00306657.1193691"},{"key":"e_1_2_9_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/cjp2.216"},{"key":"e_1_2_9_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/hed.26489"},{"key":"e_1_2_9_19_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41698-025-00974-x"},{"key":"e_1_2_9_20_2","doi-asserted-by":"publisher","DOI":"10.1155\/crid\/9151514"},{"key":"e_1_2_9_21_2","doi-asserted-by":"publisher","DOI":"10.1002\/dvg.23490"},{"key":"e_1_2_9_22_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0757.2000.2240102.x"},{"key":"e_1_2_9_23_2","doi-asserted-by":"publisher","DOI":"10.4103\/ccd.ccd_480_18"},{"key":"e_1_2_9_24_2","doi-asserted-by":"publisher","DOI":"10.15644\/asc48\/1\/6"},{"key":"e_1_2_9_25_2","doi-asserted-by":"publisher","DOI":"10.4317\/jced.57646"},{"key":"e_1_2_9_26_2","volume-title":"Oral & Maxillofacial Pathology","author":"Neville B. 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