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Without timely endodontic intervention, this pathology can lead to significant bone tissue destruction due to its growth pattern, necessitating both endodontic and surgical approaches to halt its progression and remove the involved tissue. This case study details the management of a 23\u2010year\u2010old patient with a history of prior trauma, presenting with pressure in the anterior maxillary region. Tomographic examination revealed a hypodense area involving Teeth 2.1, 2.2, and 2.3. A surgical approach involving enucleation and endodontic treatment was undertaken. The diagnosis was confirmed histopathologically, and follow\u2010up radiographs demonstrated satisfactory bone filling.<\/jats:p>","DOI":"10.1155\/crid\/9977128","type":"journal-article","created":{"date-parts":[[2025,4,28]],"date-time":"2025-04-28T08:35:42Z","timestamp":1745829342000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["A Radicular Cyst With Extensive Bone Loss Requires Surgical and Endodontic Management: Case Presentation and Literature Review"],"prefix":"10.1155","volume":"2025","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4335-9163","authenticated-orcid":false,"given":"Juan Mart\u00edn","family":"Pes\u00e1ntez Alvarado","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4947-8411","authenticated-orcid":false,"given":"Milton Fabricio","family":"Lafebre Carrasco","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,4,28]]},"reference":[{"key":"e_1_2_9_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2020.05.025"},{"key":"e_1_2_9_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.prp.2020.153223"},{"key":"e_1_2_9_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tripleo.2005.03.038"},{"key":"e_1_2_9_4_2","volume-title":"Oral and Maxillofacial Surgery Clinics of North America","author":"Assael","year":"1991"},{"key":"e_1_2_9_5_2","article-title":"Quistes de los maxilares: Revisi\u00f3n bibliogr\u00e1fica","volume":"43","author":"Rodr\u00edguez Garc\u00eda L. 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