{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T23:34:41Z","timestamp":1792712081507,"version":"4.5.0"},"reference-count":55,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,1,30]],"date-time":"2025-01-30T00:00:00Z","timestamp":1738195200000},"content-version":"vor","delay-in-days":29,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Case Reports in Endocrinology"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:p>\n                    <jats:bold>Background:<\/jats:bold>\n                    Severe hypertriglyceridemia (triglycerides (TGs) &gt;1000\u2009mg\/dL, &gt;11.3\u2009mmol\/L) is a rare but potentially morbid condition in pregnancy. Physiological changes in pregnancy may unmask or exacerbate an underlying defect in TG metabolism. When conventional therapies are ineffective in controlling TG levels, a personalized management approach is needed. We present a case of severe hypertriglyceridemic pancreatitis successfully managed with niacin, a treatment that has seen limited use in pregnancy due to the paucity of available data.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Case Presentation:<\/jats:bold>\n                    A 29\u2010year\u2010old pregnant woman with a history of cholecystectomy and a prepregnancy BMI of 30.6\u2009kg\/m\n                    <jats:sup>2<\/jats:sup>\n                    presented at 12 weeks\u2019 gestation with acute pancreatitis and severe hypertriglyceridemia (6900\u2009mg\/dL, 77.9\u2009mmol\/L). After initial management with intravenous (IV) fluids, insulin infusion, and a low\u2010fat diet, her TG levels improved. However, she was readmitted at 23 weeks\u2019 gestation with recurrent hypertriglyceridemia (2872\u2009mg\/dL, 32.4\u2009mmol\/L), requiring a more aggressive insulin regimen. Despite various interventions, including omega\u20103 fatty acids (O3FAs), fenofibrate, and central venous catheter insulin infusion, her TG levels remained elevated, necessitating early delivery at 34 weeks\u2019 gestation. Her postpartum recovery included continued TG management with fenofibrate and O3FAs. Four years later, during a second pregnancy, she presented with similar hypertriglyceridemia, managed with diet, metformin, fenofibrate, and insulin. Due to persistent hypertriglyceridemia (&gt;3000\u2009mg\/dL, 33.9 mmol\/L), niacin was added as an additional therapy and titrated to 2000\u2009mg\/day, which successfully sustained TG levels below 1000\u2009mg\/dL (11.3\u2009mmol\/L) through the remainder of her pregnancy. She delivered her second child via cesarean section at 35 weeks\u2019 gestation due to preeclampsia. Both children had developmental issues, with her first child diagnosed with attention\u2010deficient hyperactivity disorder (ADHD) and her second child with autism spectrum disorder and motor delays. The patient was encouraged to remain on long\u2010term management for her metabolic condition.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusions:<\/jats:bold>\n                    Managing severe hypertriglyceridemia during pregnancy is challenging due to uncertainties about treatment efficacy and safety. Timely reduction of maternal TGs is essential to prevent complications and requires adjustments throughout pregnancy. This case demonstrates the effectiveness and safety of niacin, often underutilized due to perceived side effects, in managing severe hypertriglyceridemia in pregnancy when other treatments were inadequate.\n                  <\/jats:p>","DOI":"10.1155\/crie\/2644678","type":"journal-article","created":{"date-parts":[[2025,1,30]],"date-time":"2025-01-30T12:05:03Z","timestamp":1738238703000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Management of Severe Hypertriglyceridemia in Pregnancy With Niacin: Reevaluating Safety and Therapeutic 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