{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T07:20:14Z","timestamp":1787642414696,"version":"build-2736575974"},"reference-count":17,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T00:00:00Z","timestamp":1787529600000},"content-version":"vor","delay-in-days":235,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Case Reports in Endocrinology"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To report a clinical case of complete hydatidiform mole (CHM) with significant impact on thyroid function, associated with the development of acute pulmonary edema in the period following uterine evacuation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case Report<\/jats:title>\n                    <jats:p>A 46\u2010year\u2010old woman sought medical attention due to significant vaginal bleeding, with marked elevation of serum \u03b2\u2010hCG (greater than 300,000\u2009mIU\/mL), as well as transvaginal ultrasonography with imaging suggestive of HM. After uterine evacuation, the patient developed acute respiratory failure with dyspnea and chest pain, requiring intensive care admission and mechanical ventilation. Thyroid storm was diagnosed based on clinical presentation, laboratory findings, and Burch\u2013Wartofsky criteria (50 points). Additional investigations excluded pulmonary embolism and primary thyroid disease. Removal of the HM resulted in decreased \u03b2\u2010hCG titers; however, normalization of serum thyroid hormone levels occurred only after pharmacological treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This case highlights the potential progression of hCG\u2010mediated thyrotoxicosis to thyroid crisis after uterine evacuation and emphasizes the importance of early recognition and treatment of severe hyperthyroidism in patients with HM. Early diagnosis and prompt management may help prevent thyroid crisis and cardiopulmonary complications. This case also demonstrates that acute pulmonary edema and transient cardiac dysfunction may occur as severe manifestations of thyroid crisis associated with gestational trophoblastic disease (GTD). Furthermore, close collaboration among obstetric, endocrine, and critical care teams is essential to optimize outcomes in complex presentations.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1155\/crie\/3431031","type":"journal-article","created":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T06:42:59Z","timestamp":1787640179000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Acute Pulmonary Edema as a Manifestation of Thyroid Crisis From Hydatidiform Mole: A Case Report"],"prefix":"10.1155","volume":"2026","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-5812-8393","authenticated-orcid":false,"given":"Tha\u00eds Tiemi","family":"Yauti","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-5693-1428","authenticated-orcid":false,"given":"Lin","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-5441-8043","authenticated-orcid":false,"given":"Fernanda Verza","family":"Azevedo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-3058-649X","authenticated-orcid":false,"given":"Paula Nina","family":"Shiroma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-6745-4877","authenticated-orcid":false,"given":"Cleomar Ana de Souza","family":"Valentim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-6855-4278","authenticated-orcid":false,"given":"Mariana Soares Dalla Mariga","family":"Jorgino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,24]]},"reference":[{"key":"e_1_2_11_1_2","doi-asserted-by":"publisher","DOI":"10.1590\/S0100-72032009000200008"},{"key":"e_1_2_11_2_2","doi-asserted-by":"publisher","DOI":"10.1590\/S0034-70942011000500010"},{"key":"e_1_2_11_3_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13044-024-00190-y"},{"key":"e_1_2_11_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/uog.2592"},{"key":"e_1_2_11_5_2","doi-asserted-by":"publisher","DOI":"10.7860\/JCDR\/2017\/28561.10133"},{"key":"e_1_2_11_6_2","volume-title":"StatPearls","author":"Pokhrel 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Storm in the United States","volume":"15","author":"Desai R.","year":"2020","journal-title":"Internal and Emergency Medicine"},{"key":"e_1_2_11_17_2","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.37582"}],"container-title":["Case Reports in Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/crie\/3431031","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1155\/crie\/3431031","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/crie\/3431031","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T06:43:01Z","timestamp":1787640181000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/crie\/3431031"}},"subtitle":[],"editor":[{"given":"Kalyani","family":"Sen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":17,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["10.1155\/crie\/3431031"],"URL":"https:\/\/doi.org\/10.1155\/crie\/3431031","archive":["Portico"],"relation":{},"ISSN":["2090-6501","2090-651X"],"issn-type":[{"value":"2090-6501","type":"print"},{"value":"2090-651X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"2025-10-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication 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