{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T23:38:20Z","timestamp":1789601900769,"version":"build-2803163510"},"reference-count":26,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,6,18]],"date-time":"2025-06-18T00:00:00Z","timestamp":1750204800000},"content-version":"vor","delay-in-days":168,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Case Reports in Endocrinology"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:p>Most cases of primary hyperparathyroidism (PHPT) are sporadic and are caused by parathyroid adenomas. Hereditary forms may occur in up to 10% of PHPT patients and are more frequent in younger patients. The hyperparathyroidism\u2010jaw tumor (HPT\u2010JT) syndrome is characterized by PHPT in up to 95% of patients and ossifying fibromas in the jaw in 25%\u201350%. We describe the case of a 35\u2010year\u2010old male from Bangladesh referred to our hospital due to a voluminous right mandibular swelling: a rare nonossifying fibroma of the mandible was diagnosed. Due to functional impotence, a left shoulder magnetic resonance imaging (MRI) was performed with evidence of a pluri\u2010lobulated cyst\u2010like lesion in the proximal humeral area diagnosed as a brown tumor (BT). Subsequent tests highlighted hypercalcemia and hypophosphatemia with high PTH levels. A heterozygous CDC73 pathogenic variant c.96&gt;A p.Trp32Ter was identified. To the best of our knowledge, this is the first reported case of HPT\u2010JT syndrome related to a CDC73 pathogenic variant, associated to a BT of the arm and a rare nonossifying fibroma of the mandible.<\/jats:p>","DOI":"10.1155\/crie\/4340464","type":"journal-article","created":{"date-parts":[[2025,6,19]],"date-time":"2025-06-19T00:34:51Z","timestamp":1750293291000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Hyperparathyroidism\u2010Jaw Tumor Syndrome Associated to a CDC73 Gene Pathogenic VARIANT and a Nonossifying Desmoplastic Fibroma of the Mandible"],"prefix":"10.1155","volume":"2025","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6622-4267","authenticated-orcid":false,"given":"Castellano","family":"Elena","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Craparo","family":"Andrea","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabrizia","family":"Di Giovanni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linari","family":"Alessandra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fortunato","family":"Mirella","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maff\u00e8","family":"Antonella","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,6,18]]},"reference":[{"key":"e_1_2_15_1_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrendo.2017.104"},{"key":"e_1_2_15_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.4665"},{"key":"e_1_2_15_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/s42000-023-00508-9"},{"key":"e_1_2_15_4_2","doi-asserted-by":"publisher","DOI":"10.1210\/jendso\/bvad114.454"},{"key":"e_1_2_15_5_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa031237"},{"key":"e_1_2_15_6_2","doi-asserted-by":"publisher","DOI":"10.1530\/ERC-20-0149"},{"key":"e_1_2_15_7_2","doi-asserted-by":"publisher","DOI":"10.1159\/000510002"},{"key":"e_1_2_15_8_2","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/1761030"},{"key":"e_1_2_15_9_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2017-01249"},{"key":"e_1_2_15_10_2","first-page":"375","volume-title":"Bone Tumors","author":"Dahlin D. C.","year":"1984"},{"key":"e_1_2_15_11_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-2000-10065"},{"key":"e_1_2_15_12_2","volume-title":"Pathology and Genetics of Tumours of Soft Tissue and Bone","author":"Fornasier V.","year":"2002"},{"key":"e_1_2_15_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.anndiagpath.2009.04.004"},{"key":"e_1_2_15_14_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12105-014-0561-5"},{"key":"e_1_2_15_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mayocp.2014.08.025"},{"key":"e_1_2_15_16_2","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/2582038"},{"key":"e_1_2_15_17_2","first-page":"101","article-title":"Mandible Brown Tumor Caused by Primary Hyperparathyroidism","volume":"1","author":"Scarano A.","year":"2011","journal-title":"European Journal of Inflammation"},{"key":"e_1_2_15_18_2","first-page":"462","article-title":"Brown Tumors of the Jaw: An Atypical Manifestation of Primary Hyperparathyroidism","volume":"83","author":"Genovesi E.","year":"2023","journal-title":"Medicina"},{"key":"e_1_2_15_19_2","doi-asserted-by":"publisher","DOI":"10.12659\/AJCR.936135"},{"key":"e_1_2_15_20_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12902-023-01475-3"},{"key":"e_1_2_15_21_2","first-page":"149","article-title":"A Case of Multiple Skeletal Lesions of Brown Tumors, Mimicking Carcinoma Metastases","volume":"128","author":"Manabu H.","year":"2007","journal-title":"Archives of Orthopaedic and Trauma Surgery"},{"key":"e_1_2_15_22_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1673.2008.01963.x"},{"key":"e_1_2_15_23_2","doi-asserted-by":"publisher","DOI":"10.4158\/EP12301.OR"},{"key":"e_1_2_15_24_2","doi-asserted-by":"publisher","DOI":"10.29271\/jcpsp.2019.12.1232"},{"key":"e_1_2_15_25_2","doi-asserted-by":"publisher","DOI":"10.1097\/MAJ.0000000000000441"},{"key":"e_1_2_15_26_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12663-024-02157-w"}],"container-title":["Case Reports in Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/crie\/4340464","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1155\/crie\/4340464","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/crie\/4340464","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T13:51:33Z","timestamp":1772977893000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/crie\/4340464"}},"subtitle":[],"editor":[{"given":"Osamu","family":"Isozaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2025,1]]},"references-count":26,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,1]]}},"alternative-id":["10.1155\/crie\/4340464"],"URL":"https:\/\/doi.org\/10.1155\/crie\/4340464","archive":["Portico"],"relation":{},"ISSN":["2090-6501","2090-651X"],"issn-type":[{"value":"2090-6501","type":"print"},{"value":"2090-651X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1]]},"assertion":[{"value":"2025-03-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-05-29","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-06-18","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"4340464"}}