{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T21:38:09Z","timestamp":1773005889527,"version":"3.50.1"},"reference-count":57,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,2,9]],"date-time":"2026-02-09T00:00:00Z","timestamp":1770595200000},"content-version":"vor","delay-in-days":39,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Case Reports in Endocrinology"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:sec>\n                    <jats:title>Context<\/jats:title>\n                    <jats:p>Hypertriglyceridaemia\u2010induced pancreatitis in pregnancy (HTG\u2010IPP) is a rare but serious condition. There is a paucity of evidence\u2010based guidelines and recommendations for screening and management of HTG\u2010IPP. Individual genomics can predispose certain populations to a higher risk of developing HTG\u2010IPP.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To report on a case series of the management of four individual pregnancies complicated by HTG\u2010IPP, subsequently found to be associated with pathogenic genetic variants involved in triglyceride (TG) metabolism.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The medical records of four individual pregnancies from two metropolitan hospitals in Australia were reviewed regarding the management of their HTG\u2010IPP and genetic testing for hypertriglyceridaemia (HTG). A literature review of previous cases of HTG\u2010IPP with an identified pathogenic variant was performed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The identified genetic variants resulting in a diagnosis of HTG and HTG\u2010IPP were within glycosylphosphatidylinositol anchored high density lipoprotein binding protein 1 (GPIHBP1), lipoprotein lipase (LPL) and apolipoprotein A5 (APOA\u20105). All patients had co\u2010morbid gestational diabetes mellitus (GDM) and were of South Asian or Asian ethnicity. All four patients were effectively managed with fasting, intravenous insulin, omega\u20103 fatty acids (O3FAs) and very low\u2010fat diet (VLFD) with supplementation with medium\u2010chain TG (MCT) oil.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Further genomics research is needed to increase our understanding for its use in predicting risk of severe gestational HTG. With additional case identification, particular variants of pathogenic interest can be identified and screened for antenatally in patients with a moderate fasting HTG of more than 200\u2009mg\/dL (11.1\u2009mmol\/L) in the absence of other causative factors. Pre\u2010conception optimisation of TGs and regular monitoring in pregnancy can reduce the incidence and disease burden associated with HTG\u2010IPP and HTG.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1155\/crie\/5330997","type":"journal-article","created":{"date-parts":[[2026,2,9]],"date-time":"2026-02-09T22:27:12Z","timestamp":1770676032000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Genetic Insights on Hypertriglyceridaemia\u2010Induced Acute Pancreatitis in Pregnancy: A Case Series and Literature Review"],"prefix":"10.1155","volume":"2026","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2522-6519","authenticated-orcid":false,"given":"Christopher Son","family":"Nguyen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1125-2521","authenticated-orcid":false,"given":"Nicholas","family":"Adams","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5219-3241","authenticated-orcid":false,"given":"Emily","family":"Gianatti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9958-8489","authenticated-orcid":false,"given":"I-Lynn","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3990-9919","authenticated-orcid":false,"given":"Dev","family":"Kevat","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,2,9]]},"reference":[{"key":"e_1_2_12_1_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2012-1250"},{"key":"e_1_2_12_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.2006.00889.x"},{"key":"e_1_2_12_3_2","doi-asserted-by":"publisher","DOI":"10.4103\/2229-516X.117090"},{"key":"e_1_2_12_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/1471-0528.12375"},{"key":"e_1_2_12_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2011.07.037"},{"key":"e_1_2_12_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1526-9523(02)00417-8"},{"key":"e_1_2_12_7_2","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0b013e318185a032"},{"key":"e_1_2_12_8_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12884-022-04742-8"},{"key":"e_1_2_12_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-2275(20)40102-6"},{"key":"e_1_2_12_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0009-9120(02)00283-7"},{"key":"e_1_2_12_11_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2393-4-27"},{"key":"e_1_2_12_12_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-124-4-199602150-00007"},{"key":"e_1_2_12_13_2","doi-asserted-by":"publisher","DOI":"10.3904\/kjim.2013.28.5.609"},{"key":"e_1_2_12_14_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0129488"},{"key":"e_1_2_12_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacl.2015.09.010"},{"key":"e_1_2_12_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacl.2016.12.006"},{"key":"e_1_2_12_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacl.2017.08.008"},{"key":"e_1_2_12_18_2","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.R009720"},{"key":"e_1_2_12_19_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2796.1992.tb01256.x"},{"key":"e_1_2_12_20_2","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2012-302779"},{"key":"e_1_2_12_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2018.12.019"},{"key":"e_1_2_12_22_2","doi-asserted-by":"publisher","DOI":"10.1111\/tog.12887"},{"key":"e_1_2_12_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0009-8981(97)00144-7"},{"key":"e_1_2_12_24_2","doi-asserted-by":"publisher","DOI":"10.1097\/MOL.0b013e3283319a1d"},{"key":"e_1_2_12_25_2","doi-asserted-by":"publisher","DOI":"10.1177\/1933719108330569"},{"key":"e_1_2_12_26_2","doi-asserted-by":"publisher","DOI":"10.1111\/jdi.13273"},{"key":"e_1_2_12_27_2","doi-asserted-by":"publisher","DOI":"10.1503\/cmaj.100378"},{"key":"e_1_2_12_28_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2013-1570"},{"key":"e_1_2_12_29_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2021.41321"},{"key":"e_1_2_12_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2021.09.010"},{"key":"e_1_2_12_31_2","doi-asserted-by":"publisher","DOI":"10.1111\/bcp.15423"},{"key":"e_1_2_12_32_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02788396"},{"key":"e_1_2_12_33_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2796.1998.00306.x"},{"key":"e_1_2_12_34_2","doi-asserted-by":"publisher","DOI":"10.1002\/mgg3.1048"},{"key":"e_1_2_12_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cca.2008.10.016"},{"key":"e_1_2_12_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacl.2018.09.007"},{"key":"e_1_2_12_37_2","doi-asserted-by":"publisher","DOI":"10.1210\/jendso\/bvab048.635"},{"key":"e_1_2_12_38_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12884-020-02965-1"},{"key":"e_1_2_12_39_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacl.2023.03.005"},{"key":"e_1_2_12_40_2","doi-asserted-by":"publisher","DOI":"10.5551\/jat.62734"},{"key":"e_1_2_12_41_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosissup.2019.08.032"},{"key":"e_1_2_12_42_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1262-3636(07)70197-0"},{"key":"e_1_2_12_43_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000441-199504000-00005"},{"key":"e_1_2_12_44_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pathol.2018.10.014"},{"key":"e_1_2_12_45_2","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.122.318445"},{"key":"e_1_2_12_46_2","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2020.00455"},{"key":"e_1_2_12_47_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosissup.2016.10.002"},{"key":"e_1_2_12_48_2","volume-title":"APOE Screen","author":"Sonic Genetics","year":"2024"},{"key":"e_1_2_12_49_2","unstructured":"Hamilton-CraigI. WattsG. andSullivanD. The Cardiac Society of Australia and New Zealand: Diagnosis and Management of Familial Hypercholesterolaemia-Position Statement Accessed 6 June 2024https:\/\/www.csanz.edu.au\/wp-content\/uploads\/2017\/07\/Familial-Hypercholesterolaemia_ratified_-25-Nov-2016.pdf%3E."},{"key":"e_1_2_12_50_2","doi-asserted-by":"publisher","DOI":"10.3390\/jcm9123954"},{"key":"e_1_2_12_51_2","volume-title":"Endotext","author":"Feingold K. R."},{"key":"e_1_2_12_52_2","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.110.003871"},{"key":"e_1_2_12_53_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/36.5.950"},{"key":"e_1_2_12_54_2","doi-asserted-by":"publisher","DOI":"10.1177\/1753495X15594082"},{"key":"e_1_2_12_55_2","doi-asserted-by":"publisher","DOI":"10.1097\/00008571-200206000-00007"},{"key":"e_1_2_12_56_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2008.02.029"},{"key":"e_1_2_12_57_2","volume-title":"Endotext","author":"Feingold K. R."}],"container-title":["Case Reports in Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/crie\/5330997","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1155\/crie\/5330997","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/crie\/5330997","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T19:20:01Z","timestamp":1772997601000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/crie\/5330997"}},"subtitle":[],"editor":[{"given":"Kalyani","family":"Sen","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":57,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["10.1155\/crie\/5330997"],"URL":"https:\/\/doi.org\/10.1155\/crie\/5330997","archive":["Portico"],"relation":{},"ISSN":["2090-6501","2090-651X"],"issn-type":[{"value":"2090-6501","type":"print"},{"value":"2090-651X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"2024-12-07","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-14","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-02-09","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"5330997"}}