{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T20:39:02Z","timestamp":1780605542800,"version":"3.54.1"},"reference-count":16,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,7,15]],"date-time":"2025-07-15T00:00:00Z","timestamp":1752537600000},"content-version":"vor","delay-in-days":195,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Case Reports in Endocrinology"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:p>\n                    <jats:bold>Introduction:<\/jats:bold>\n                    Jod\u2010Basedow syndrome and iodine\u2010induced hypothyroidism are rare but clinically significant complications of iodine exposure. We report a unique case of a 14\u2010year\u2010old boy with congenital heart disease, who developed sequential iodine\u2010induced hypothyroidism due to failure to escape from the Wolff\u2013Chaikoff effect, followed by hyperthyroidism (Jod\u2010Basedow syndrome) after additional exposure to iodinated contrast.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Case Presentation:<\/jats:bold>\n                    The patient is a 14\u2010year\u2010old male with a history of complex congenital cardiac defects. He underwent a Fontan procedure to manage his single\u2010ventricle physiology, resulting in plastic bronchitis requiring lymphatic intervention and cardiac catheterization. At age 15, he developed hypothyroidism requiring levothyroxine, but 6\u2009months later presented with symptoms and labs confirming hyperthyroidism following CT scan with IV iodinated contrast. Levothyroxine was discontinued, and methimazole was initiated to manage his hyperthyroidism.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusion:<\/jats:bold>\n                    Iodine\u2010induced hypothyroidism and Jod\u2010Basedow syndrome should be considered potential complications for patients who undergo iodine exposure. This case highlights the importance of vigilant thyroid monitoring in congenital heart disease patients who are undergoing frequent radiation and iodine contrast exposure. In this patient, both his hypothyroidism and hyperthyroidism were successfully managed, but his overall condition deteriorated, ultimately requiring a heart transplant. This case underscores the importance of close monitoring of thyroid hormone levels in complex cardiac patients who undergo repeated exposure to iodinated contrast during procedures and imaging studies.\n                  <\/jats:p>","DOI":"10.1155\/crie\/6859739","type":"journal-article","created":{"date-parts":[[2025,7,17]],"date-time":"2025-07-17T02:34:44Z","timestamp":1752719684000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Hypothyroidism and Hyperthyroidism in an Adolescent With Complex Congenital Heart Disease Exposed to Iodinated Contrast Media: Case Report"],"prefix":"10.1155","volume":"2025","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6899-4126","authenticated-orcid":false,"given":"Elizabeth S.","family":"Sandberg","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6373-1968","authenticated-orcid":false,"given":"Jacqueline S.","family":"Fisher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,7,15]]},"reference":[{"key":"e_1_2_9_1_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2018-00960"},{"key":"e_1_2_9_2_2","doi-asserted-by":"publisher","DOI":"10.1210\/js.2017-00174"},{"key":"e_1_2_9_3_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2014-3292"},{"key":"e_1_2_9_4_2","doi-asserted-by":"publisher","DOI":"10.1001\/archinternmed.2011.677"},{"key":"e_1_2_9_5_2","doi-asserted-by":"publisher","DOI":"10.1210\/clinem\/dgae304"},{"key":"e_1_2_9_6_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcp1709318"},{"key":"e_1_2_9_7_2","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2016.0229.correx"},{"key":"e_1_2_9_8_2","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/5930515"},{"key":"e_1_2_9_9_2","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/792745"},{"key":"e_1_2_9_10_2","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/980283"},{"key":"e_1_2_9_11_2","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.5960"},{"key":"e_1_2_9_12_2","first-page":"1816","article-title":"Jod-Basedow Syndrome Following Oral Iodine and Radioiodinated-Antibody Administration","volume":"38","author":"El-Shirbiny A. M.","year":"1997","journal-title":"Journal of Nuclear Medicine"},{"key":"e_1_2_9_13_2","first-page":"1013","article-title":"Jod-Basedow Effect Due to Prolonged Use of Lugol Solution-Case Report","volume":"118","author":"Leu\u015ftean L.","year":"2014","journal-title":"Revista Medico-Chirurgicala a Societatii de Medici si Naturalisti Din Iasi"},{"key":"e_1_2_9_14_2","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/2683120"},{"key":"e_1_2_9_15_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-0036-1584879"},{"key":"e_1_2_9_16_2","article-title":"Contrast Induced Thyrotoxicosis in a Patient With New Onset Atrial Fibrillation: A Case Report and Review","volume":"6","author":"Adler J.","year":"2013","journal-title":"Journal of Atrial Fibrillation"}],"container-title":["Case Reports in Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/crie\/6859739","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1155\/crie\/6859739","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/crie\/6859739","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T13:51:36Z","timestamp":1772977896000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/crie\/6859739"}},"subtitle":[],"editor":[{"given":"Kalyani","family":"Sen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2025,1]]},"references-count":16,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,1]]}},"alternative-id":["10.1155\/crie\/6859739"],"URL":"https:\/\/doi.org\/10.1155\/crie\/6859739","archive":["Portico"],"relation":{},"ISSN":["2090-6501","2090-651X"],"issn-type":[{"value":"2090-6501","type":"print"},{"value":"2090-651X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1]]},"assertion":[{"value":"2025-04-01","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-06-12","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-07-15","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"6859739"}}