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When combined with fulvestrant, it is approved for hormone receptor\u2010positive advanced breast cancer. Capivasertib therapy frequently causes hyperglycemia, including diabetic ketoacidosis (DKA). Ensure glycemic control before initiation and maintain ongoing blood glucose monitoring to reduce the risk of this potentially fatal complication. We present a case of metastatic breast cancer with initially controlled blood glucose who developed ketoacidosis and myocardial infarction during capivasertib therapy.<\/jats:p>","DOI":"10.1155\/crie\/6940757","type":"journal-article","created":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T05:16:35Z","timestamp":1791782195000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Capivasertib\u2010Associated Diabetic Ketoacidosis With Concurrent Myocardial Injury in a Patient With Pre\u2010Existing Coronary Artery Disease"],"prefix":"10.1155","volume":"2026","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-0559-046X","authenticated-orcid":false,"given":"Rabih A.","family":"Noun","sequence":"first","affiliation":[{"name":"Cardiology Specialist Internal Medicine Department Ahmadi Hospital  Ahmadi Kuwait"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3658-4709","authenticated-orcid":false,"given":"Ossama Sajeh","family":"Maadarani","sequence":"additional","affiliation":[{"name":"Consultant Cardiologist Internal Medicine Ahmadi Hospital Kuwait Oil Company  Ahmadi Kuwait  kockw.com"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8426-8685","authenticated-orcid":false,"given":"Zouheir I.","family":"Bitar","sequence":"additional","affiliation":[{"name":"Consultant in Critical Care Medicine Internal Medicine Department Ahmadi Hospital  Ahmadi Kuwait"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,11]]},"reference":[{"key":"e_1_2_12_1_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/dju055"},{"key":"e_1_2_12_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.annonc.2021.09.019"},{"key":"e_1_2_12_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajem.2024.12.006"},{"key":"e_1_2_12_4_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1813904"},{"key":"e_1_2_12_5_2","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.57894"},{"key":"e_1_2_12_6_2","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.19295"},{"key":"e_1_2_12_7_2","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2022.822333"},{"key":"e_1_2_12_8_2","article-title":"Capivasertib-Induced Refractory Hyperglycemia in a Nondiabetic Patient With Metastatic Breast Cancer","volume":"13","author":"Darapu H.","year":"2025","journal-title":"AACE Endocrinology and Diabetes"},{"key":"e_1_2_12_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.critrevonc.2025.104793"},{"key":"e_1_2_12_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41523-025-00864-2"},{"key":"e_1_2_12_11_2","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.81513"},{"key":"e_1_2_12_12_2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.clbc.2024.09.017","article-title":"Effective Strategies for the Prevention and Mitigation of Phosphatidylinositol-3-Kinase Inhibitor-Associated Hyperglycemia: Optimizing Patient Care","volume":"25","author":"Moore H. 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