{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,26]],"date-time":"2026-04-26T08:38:39Z","timestamp":1777192719751,"version":"3.51.4"},"reference-count":14,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,4,26]],"date-time":"2026-04-26T00:00:00Z","timestamp":1777161600000},"content-version":"vor","delay-in-days":115,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Case Reports in Endocrinology"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Pheochromocytomas are rare catecholamine\u2010producing neuroendocrine tumors that present with the classical triad of paroxysmal hypertension, palpitations, and sweating; however, this presentation is seen in less than 1\/4 of pheochromocytoma patients. Hypertension is usually the predominant manifestation. Atypical manifestations, including renal involvement, are infrequent and may delay diagnosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case Presentation<\/jats:title>\n                    <jats:p>We report the case of a 37\u2010year\u2010old male with no prior comorbidities who presented with progressive abdominal pain, shortness of breath, and oliguria. Laboratory evaluation demonstrated acute kidney injury with nephrotic\u2010range proteinuria, initially raising suspicion of a primary glomerular disorder. Chest imaging revealed pulmonary congestion, while abdominal imaging identified a right adrenal mass. Plasma\u2010free metanephrine and normetanephrine levels were markedly elevated, confirming pheochromocytoma. The patient underwent preoperative optimization with alpha\u2010adrenergic blockade and supportive measures, including temporary hemodialysis. A right adrenalectomy was subsequently performed, leading to complete resolution of renal dysfunction and normalization of blood pressure.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This case emphasizes the diagnostic challenge of pheochromocytoma when presenting with renal complications. Clinicians should consider adrenal tumors in the differential diagnosis of patients with unexplained acute kidney injury, as timely recognition and surgical intervention can result in full recovery.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1155\/crie\/8510972","type":"journal-article","created":{"date-parts":[[2026,4,26]],"date-time":"2026-04-26T08:27:40Z","timestamp":1777192060000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Acute Kidney Injury and Nephrotic\u2010Range Proteinuria as Initial Presentation of Pheochromocytoma: A Case Report"],"prefix":"10.1155","volume":"2026","author":[{"given":"Anum","family":"Rizwan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sajid Islam","family":"Bhatti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-8476-0734","authenticated-orcid":false,"given":"Huda","family":"Raja","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sidra","family":"German","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tajammul","family":"Waqar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1205-5426","authenticated-orcid":false,"given":"Abdullah","family":"Nadeem","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-9536-1665","authenticated-orcid":false,"given":"Nahid","family":"Raufi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,4,26]]},"reference":[{"key":"e_1_2_12_1_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2014-1498"},{"key":"e_1_2_12_2_2","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1016\/S0025-6196(25)18873-3","article-title":"Occurrence of Pheochromocytoma in Rochester, Minnesota, 1950 Through 1979","volume":"58","author":"Beard C. M.","year":"1983","journal-title":"Mayo Clinic Proceedings"},{"key":"e_1_2_12_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0025-6196(26)01464-3"},{"key":"e_1_2_12_4_2","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1056\/NEJMra1806651","article-title":"Pheochromocytoma and Paraganglioma","volume":"381","author":"Neumann H. P.","year":"2019","journal-title":"New England Journal of Medicine"},{"key":"e_1_2_12_5_2","doi-asserted-by":"publisher","DOI":"10.1677\/ERC-10-0211"},{"key":"e_1_2_12_6_2","article-title":"Clinical Profile and Outcomes of Patients With Pheochromocytoma and Paraganglioma: Audit of Two Tertiary Hospitals in South Africa","volume":"5","author":"Bulane C. M.","year":"2021","journal-title":"The Journal of the Endocrine Society"},{"key":"e_1_2_12_7_2","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.100754"},{"key":"e_1_2_12_8_2","doi-asserted-by":"publisher","DOI":"10.1097\/HJH.0b013e32834a4ce9"},{"key":"e_1_2_12_9_2","first-page":"219","article-title":"Prevalence of Cardiovascular Disease and Risk Factors in Pheochromocytoma","volume":"64","author":"Van der Horst-Schrivers A. N.","year":"2006","journal-title":"Netherlands Journal of Medicine"},{"key":"e_1_2_12_10_2","first-page":"199","article-title":"Sindrome nefrosica e feocromocitoma. Descrizione di un raro caso clinico [The Nephrotic Syndrome and Pheochromocytoma. A Report of a Rare Clinical Case]","volume":"145","author":"Tirri R.","year":"1994","journal-title":"Clinical Therapeutics"},{"key":"e_1_2_12_11_2","first-page":"332","article-title":"Pheochromocytoma Associated With Nephrotic Syndrome: A Case Report and Review of the Literature","volume":"39","author":"Osawa S.","year":"1993","journal-title":"Clinical Nephrology"},{"key":"e_1_2_12_12_2","first-page":"625","article-title":"Atypical Manifestations of Pheochromocytoma in Clinical Practice: A Multicenter Retrospective Study in Korea","volume":"61","author":"Lee M. J.","year":"2014","journal-title":"Endocrine Journal"},{"key":"e_1_2_12_13_2","first-page":"506","article-title":"Clinical and Experimental Aspects of Pheochromocytoma","volume":"13","author":"Manger W. M.","year":"2002","journal-title":"Trends in Endocrinology and Metabolism"},{"key":"e_1_2_12_14_2","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-15-0483"}],"container-title":["Case Reports in Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/crie\/8510972","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1155\/crie\/8510972","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/crie\/8510972","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,26]],"date-time":"2026-04-26T08:27:46Z","timestamp":1777192066000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/crie\/8510972"}},"subtitle":[],"editor":[{"given":"Kalyani","family":"Sen","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":14,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["10.1155\/crie\/8510972"],"URL":"https:\/\/doi.org\/10.1155\/crie\/8510972","archive":["Portico"],"relation":{},"ISSN":["2090-6501","2090-651X"],"issn-type":[{"value":"2090-6501","type":"print"},{"value":"2090-651X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"2025-11-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-30","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-26","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"8510972"}}