{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T05:03:56Z","timestamp":1784783036214,"version":"3.55.0"},"reference-count":32,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T00:00:00Z","timestamp":1784678400000},"content-version":"vor","delay-in-days":202,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100006013","name":"United Arab Emirates University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006013","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Case Reports in Genetics"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Germline genetic testing is integral to precision oncology in prostate cancer (PCa), particularly for men with pathogenic or likely pathogenic (P\/LP)\n                      <jats:italic>BRCA1\/2<\/jats:italic>\n                      variants, where results have therapeutic and hereditary implications. However, data from the Middle East remain limited regarding real\u2010world implementation of genetic counseling and its influence on family communication and cascade testing.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>\n                      To describe the role and challenges of genetic counseling for\n                      <jats:italic>BRCA2<\/jats:italic>\n                      \u2010associated PCa in Omani patients, focusing on family communication, risk awareness, and cascade testing uptake.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      This descriptive, retrospective case series included nine men with PCa carrying P\/LP\n                      <jats:italic>BRCA2<\/jats:italic>\n                      variants identified between September 2021 and December 2025. Clinical and genetic data were extracted from electronic records, and genetic counseling documentation was reviewed for family history, psychosocial context, communication patterns, and cascade testing. Quantitative data were summarized descriptively. Qualitative content analysis of counseling records identified recurring sociocultural and communication\u2010related factors.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Findings and Discussion<\/jats:title>\n                    <jats:p>\n                      Patients were aged 60\u201376\u2009years at the time of PCa diagnosis, with varied educational backgrounds and disease stages, and all carried\n                      <jats:italic>BRCA2<\/jats:italic>\n                      variants. Awareness of diagnosis differed, with some patients partially informed or unaware. These findings underscore the pivotal role of genetic counseling in translating\n                      <jats:italic>BRCA2<\/jats:italic>\n                      molecular results into actionable strategies for patients and families. Family\u2010mediated protective nondisclosure and decision\u2010making were prominent. Cascade testing uptake was higher in families with younger or medically informed relatives and lower where stigma or fear prevailed.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      In this single\u2010center Omani case series, effective counseling for\n                      <jats:italic>BRCA2<\/jats:italic>\n                      \u2010associated PCa required navigating complex cultural dynamics related to family\u2010mediated communication and decision\u2010making. Integrating culturally sensitive, family\u2010centered genetic counseling into routine oncology care may save lives by empowering families to act earlier on inherited risk.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1155\/crig\/2823337","type":"journal-article","created":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T04:33:18Z","timestamp":1784781198000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["From Diagnosis to Disclosure: Navigating Genetic Counseling Dilemmas in\n                    <i>BRCA2<\/i>\n                    \u2010Associated Prostate Cancer in the Middle East"],"prefix":"10.1155","volume":"2026","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8323-3517","authenticated-orcid":false,"given":"Chantel","family":"van Wyk","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reem","family":"Abdulrahim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilse","family":"Crous","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3097-2420","authenticated-orcid":false,"given":"Abeer","family":"Al Saegh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amira","family":"Al Balushi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bushra","family":"Al Muhairi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Al Kiyumi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suad","family":"Al Malki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Munjid","family":"Al Harthy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,22]]},"reference":[{"key":"e_1_2_16_1_2","doi-asserted-by":"publisher","DOI":"10.3390\/CURRONCOL30020178"},{"key":"e_1_2_16_2_2","doi-asserted-by":"publisher","DOI":"10.1200\/GO.23.00337"},{"key":"e_1_2_16_3_2","doi-asserted-by":"publisher","DOI":"10.1080\/2090598X.2020.1781386"},{"key":"e_1_2_16_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/s13187-019-01556-9"},{"key":"e_1_2_16_5_2","doi-asserted-by":"publisher","DOI":"10.15537\/smj.2018.5.21986"},{"key":"e_1_2_16_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/S41585-022-00580-7"},{"key":"e_1_2_16_7_2","doi-asserted-by":"publisher","DOI":"10.1200\/GO.24.00042"},{"key":"e_1_2_16_8_2","doi-asserted-by":"publisher","DOI":"10.14740\/WJON1896"},{"key":"e_1_2_16_9_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-018-4098-y"},{"key":"e_1_2_16_10_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10897-008-9183-y"},{"key":"e_1_2_16_11_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0265387"},{"key":"e_1_2_16_12_2","doi-asserted-by":"publisher","DOI":"10.1177\/1557988315610806"},{"key":"e_1_2_16_13_2","doi-asserted-by":"publisher","DOI":"10.1177\/1557988317753241"},{"key":"e_1_2_16_14_2","doi-asserted-by":"crossref","DOI":"10.1200\/JCO.2021.39.15_suppl.10584","article-title":"An Evaluation of Gender Discrepancies in Genetic Referrals for BRCA Testing for Indicated Malignancies","volume":"39","author":"Smith W.","year":"2021","journal-title":"Journal of Clinical Oncology"},{"key":"e_1_2_16_15_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-019-5463-1"},{"key":"e_1_2_16_16_2","doi-asserted-by":"publisher","DOI":"10.1186\/S40246-025-00770-5"},{"key":"e_1_2_16_17_2","doi-asserted-by":"publisher","DOI":"10.4103\/SHB.SHB_208_24"},{"key":"e_1_2_16_18_2","doi-asserted-by":"publisher","DOI":"10.1177\/15330338251336829"},{"key":"e_1_2_16_19_2","doi-asserted-by":"publisher","DOI":"10.1002\/jgc4.70139"},{"key":"e_1_2_16_20_2","doi-asserted-by":"publisher","DOI":"10.1002\/JGC4.1773"},{"key":"e_1_2_16_21_2","doi-asserted-by":"publisher","DOI":"10.4236\/ojn.2013.31017"},{"key":"e_1_2_16_22_2","doi-asserted-by":"publisher","DOI":"10.12968\/bjon.2022.31.10"},{"key":"e_1_2_16_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.socscimed.2019.112592"},{"key":"e_1_2_16_24_2","doi-asserted-by":"publisher","DOI":"10.1002\/jgc4.1797"},{"key":"e_1_2_16_25_2","doi-asserted-by":"publisher","DOI":"10.1038\/S41525-019-0110-Y"},{"key":"e_1_2_16_26_2","doi-asserted-by":"publisher","DOI":"10.1159\/000540466"},{"key":"e_1_2_16_27_2","doi-asserted-by":"publisher","DOI":"10.1038\/d41586-019-02015-7"},{"key":"e_1_2_16_28_2","doi-asserted-by":"publisher","DOI":"10.1177\/1557988320924932"},{"key":"e_1_2_16_29_2","unstructured":"DickmanS. 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