{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T09:11:27Z","timestamp":1779354687317,"version":"3.51.4"},"reference-count":16,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T00:00:00Z","timestamp":1779321600000},"content-version":"vor","delay-in-days":140,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Case Reports in Genetics"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:p>Male infertility can be caused by various microdeletions of the azoospermia factor (AZF) gene, some of which require sperm retrieval techniques for treatment. Yet, the likelihood of success with such techniques depends partly on the affected AZF gene segment. For patients with select AZF microdeletions, other options such as in vitro fertilization, sperm donation, and adoption may be more appropriate. We present a case about a 32\u2010year\u2010old male diagnosed with infertility due to azoospermia from a complete AZFb\u2009+\u2009c deletion, which is unlikely to be successfully treated with sperm retrieval techniques. The goal of this case report is to highlight the significance of earlier diagnosis of AZF microdeletions in infertile males to facilitate earlier genetic counseling and pursuit of the most appropriate intervention.<\/jats:p>","DOI":"10.1155\/crig\/2832648","type":"journal-article","created":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T08:44:49Z","timestamp":1779353089000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A Case Highlighting the Importance of Timely Intervention for a Male With AZFb\u2009+\u2009c Microdeletion"],"prefix":"10.1155","volume":"2026","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-3617-9600","authenticated-orcid":false,"given":"Rahul","family":"Atodaria","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2792-5161","authenticated-orcid":false,"given":"Randa","family":"Abdelmasih","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,5,21]]},"reference":[{"key":"e_1_2_10_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.beem.2020.101471"},{"key":"e_1_2_10_2_2","doi-asserted-by":"publisher","DOI":"10.1210\/clinem\/dgaa781"},{"key":"e_1_2_10_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/rmb2.12336"},{"key":"e_1_2_10_4_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12894-024-01503-x"},{"key":"e_1_2_10_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41436-020-0916-0"},{"key":"e_1_2_10_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/andr.13514"},{"key":"e_1_2_10_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10815-022-02601-1"},{"key":"e_1_2_10_8_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12894-021-00834-3"},{"key":"e_1_2_10_9_2","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/deaf043"},{"key":"e_1_2_10_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2025.03.006"},{"key":"e_1_2_10_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.gene.2020.144389"},{"key":"e_1_2_10_12_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12958-018-0330-5"},{"key":"e_1_2_10_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2023.10.029"},{"key":"e_1_2_10_14_2","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/den124"},{"key":"e_1_2_10_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2011.01.162"},{"key":"e_1_2_10_16_2","doi-asserted-by":"publisher","DOI":"10.1056\/nejmcp2311150"}],"container-title":["Case Reports in Genetics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/crig\/2832648","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1155\/crig\/2832648","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/crig\/2832648","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T08:44:50Z","timestamp":1779353090000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/crig\/2832648"}},"subtitle":[],"editor":[{"given":"John Lalith","family":"Charles Richard","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":16,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["10.1155\/crig\/2832648"],"URL":"https:\/\/doi.org\/10.1155\/crig\/2832648","archive":["Portico"],"relation":{},"ISSN":["2090-6544","2090-6552"],"issn-type":[{"value":"2090-6544","type":"print"},{"value":"2090-6552","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"2025-12-15","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-17","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-21","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"2832648"}}