{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T06:48:02Z","timestamp":1791787682676,"version":"4.3.4"},"reference-count":13,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T00:00:00Z","timestamp":1791676800000},"content-version":"vor","delay-in-days":283,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Case Reports in Genetics"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Nonmosaic Trisomy 9 is a rare chromosomal abnormality, accounting for approximately 2.2%\u20132.7% of spontaneous abortions caused by autosomal trisomies, and is characterized by a heterogeneous multisystem phenotype and an extremely poor prognosis. Prenatal imaging may demonstrate severe multisystem abnormalities; however, these findings are not specific to Trisomy 9, making cytogenetic testing essential for definitive diagnosis. We report a case of prenatally diagnosed apparently nonmosaic Trisomy 9 in which diagnosis enabled individualized perinatal care.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case<\/jats:title>\n                    <jats:p>A 44\u2010year\u2010old multiparous woman was referred to our hospital at 25\u2009weeks\u2019 gestation because of severe fetal growth restriction and multiple structural anomalies. Amniocentesis at 28\u2009weeks\u2019 gestation demonstrated 47,XY,+9 in all 100 examined colonies, consistent with apparently nonmosaic Trisomy 9. Following multidisciplinary counseling and shared decision\u2010making, an individualized birth plan was developed. The family wished to avoid aggressive life\u2010prolonging interventions while prioritizing the opportunity to meet their infant alive; therefore, fetal monitoring, cesarean delivery for fetal indications, and mask ventilation without further resuscitation were incorporated into the plan. Emergency cesarean delivery was performed at 36\u2009weeks and 2\u2009days for nonreassuring fetal status. The infant died approximately 9\u2009h after birth while receiving family\u2010centered palliative care.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This case highlights the clinical importance of definitive prenatal cytogenetic diagnosis in apparently nonmosaic Trisomy 9, enabling phenotype\u2010informed prognostic counseling and individualized perinatal management.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1155\/crig\/7719810","type":"journal-article","created":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T06:27:00Z","timestamp":1791786420000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Prenatal Diagnosis and Individualized Perinatal Care in Apparently Nonmosaic Trisomy 9"],"prefix":"10.1155","volume":"2026","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-9508-9404","authenticated-orcid":false,"given":"Hitoshi","family":"Isohata","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Kitasato University School of Medicine  Sagamihara Kanagawa Japan  kitasato-u.ac.jp"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshihiro","family":"Yoshimura","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Kitasato University School of Medicine  Sagamihara Kanagawa Japan  kitasato-u.ac.jp"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-7973-1890","authenticated-orcid":false,"given":"Yu","family":"Yamazaki","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Kitasato University School of Medicine  Sagamihara Kanagawa Japan  kitasato-u.ac.jp"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-8496-5994","authenticated-orcid":false,"given":"Hiroyuki","family":"Goto","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Kitasato University School of Medicine  Sagamihara Kanagawa Japan  kitasato-u.ac.jp"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-7262-9040","authenticated-orcid":false,"given":"Kyoko","family":"Hattori","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Kitasato University School of Medicine  Sagamihara Kanagawa Japan  kitasato-u.ac.jp"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-5775-7916","authenticated-orcid":false,"given":"Takao","family":"Shimaoka","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Kitasato University School of Medicine  Sagamihara Kanagawa Japan  kitasato-u.ac.jp"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4038-4275","authenticated-orcid":false,"given":"Fumio","family":"Takada","sequence":"additional","affiliation":[{"name":"Department of Medical Genetics and Genomics Kitasato University Graduate School of Medical Sciences  Sagamihara Kanagawa Japan  kitasato-u.ac.jp"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9807-9789","authenticated-orcid":false,"given":"Daigo","family":"Ochiai","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Kitasato University School of Medicine  Sagamihara Kanagawa Japan  kitasato-u.ac.jp"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,11]]},"reference":[{"key":"e_1_2_11_1_2","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.62251"},{"key":"e_1_2_11_2_2","doi-asserted-by":"publisher","DOI":"10.3389\/fgene.2023.1241245"},{"key":"e_1_2_11_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/uog.233"},{"key":"e_1_2_11_4_2","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.194.1.7997556"},{"key":"e_1_2_11_5_2","doi-asserted-by":"publisher","DOI":"10.7863\/jum.1993.12.2.103"},{"key":"e_1_2_11_6_2","doi-asserted-by":"crossref","first-page":"e84","DOI":"10.1097\/AOG.0000000000003425","article-title":"Perinatal Palliative Care ACOG Committee Opinion No. 786","volume":"134","author":"American College of Obstetricians and Gynecologists","year":"2019","journal-title":"Obstetrics and 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