{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T10:42:39Z","timestamp":1792406559228,"version":"4.4.0"},"reference-count":12,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T00:00:00Z","timestamp":1792368000000},"content-version":"vor","delay-in-days":291,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP23K01977"],"award-info":[{"award-number":["JP23K01977"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Case Reports in Immunology"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:p>Corn\u2010dependent exercise\u2010induced anaphylaxis (food\u2010dependent exercise\u2010induced anaphylaxis [FDEIA]) is rare, and its causative allergens remain poorly defined. Here, we report a case of corn\u2010dependent FDEIA and investigate candidate IgE\u2010binding proteins using immunological and proteomic analyses. A 13\u2010year\u2010old boy with a history of buckwheat allergy developed recurrent anaphylaxis during exercise after ingesting corn\u2010containing foods. An exercise challenge after ingesting 272\u2009g of sweet corn reproduced the symptoms and confirmed the diagnosis. Corn\u2010specific IgE was 3.72\u2009UA\/mL, and skin prick testing was positive. IgE immunoblotting revealed patient\u2010specific bands at ~45 and 60 kDa. Two\u2010dimensional immunoblotting and mass spectrometry identified globulin\u20101S (GLB1) and other proteins as candidate IgE\u2010binding proteins in this patient. Sequence analysis revealed significant local sequence similarity between maize GLB1 and buckwheat Fag e 5 within the second cupin domain. These findings identify GLB1 as a candidate IgE\u2010binding protein in this patient with corn\u2010dependent FDEIA. Although sequence similarities were observed between maize GLB1 and buckwheat Fag e 5, their immunological and clinical significance remains unclear, and further studies are required to determine whether cross\u2010reactivity exists.<\/jats:p>","DOI":"10.1155\/crii\/2731365","type":"journal-article","created":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T09:56:07Z","timestamp":1792403767000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Identification of a Candidate IgE\u2010Binding Maize Protein in a Patient With Corn\u2010Dependent Exercise\u2010Induced Anaphylaxis: A Case Report"],"prefix":"10.1155","volume":"2026","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6485-0528","authenticated-orcid":false,"given":"Ayako","family":"Goto","sequence":"first","affiliation":[{"name":"Department of Pediatrics School of Medicine Fukuoka University  Fukuoka Japan  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