{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T09:01:58Z","timestamp":1781686918737,"version":"3.54.5"},"reference-count":22,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T00:00:00Z","timestamp":1781654400000},"content-version":"vor","delay-in-days":167,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Case Reports in Immunology"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>The case report describes a novel finding of a homozygous variant in the coronin 1A (CORO1A) gene, associated with atypical severe combined immunodeficiency (SCID) in a 9\u2010year\u2010old female patient with recurrent infections and unique immunological features, including periodic T\u2010cell lymphocytosis and T\u2010 and B\u2010cell lymphopenia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case History and Examination<\/jats:title>\n                    <jats:p>A 9\u2010year\u2010old female with a known history of recurrent pneumonia presented to the emergency department with a 2\u2010week history of intermittent fever, progressive lethargy, and pallor. Her past medical history was remarkable for multiple hospital admissions secondary to community\u2010acquired pneumonia and urinary tract infections, totaling four admissions to date. Family history was significant for consanguinity between parents and a healthy 4\u2010year\u2010old younger male sibling. Chest computed tomography (CT) demonstrated bilateral diffuse centrilobular nodules, scattered ground\u2010glass opacities, and left lower lobe consolidation, in addition to a tree\u2010in\u2010bud pattern. Immunological evaluation revealed T\u2010cell lymphocytosis, B\u2010cell lymphopenia, and a decreased CD4\/CD8 ratio. Based on these findings, the pediatric allergy and immunology team recommended genetic testing for primary immunodeficiency. The panel identified a homozygous variant of uncertain significance (VUS) in the CORO1A gene. Pathogenic variants in CORO1A are associated with autosomal recessive CORO1A\u2010related SCID.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The novel homozygous variant in the CORO1A gene suggests the likelihood of an atypical form of SCID, characterized by periodic T\u2010cell lymphocytosis, T\u2010cell lymphopenia, B\u2010cell lymphopenia, and a low CD4\/CD8 ratio, expanding the spectrum of CORO1A deficiency.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1155\/crii\/3233892","type":"journal-article","created":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T08:49:26Z","timestamp":1781686166000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A Novel Variant of CORO1A Gene Contributing to the Development of Primary Immunodeficiency in 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