{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T19:07:00Z","timestamp":1770750420435,"version":"3.50.0"},"reference-count":31,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T00:00:00Z","timestamp":1770681600000},"content-version":"vor","delay-in-days":40,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100003970","name":"Isfahan University of Medical Sciences","doi-asserted-by":"publisher","award":["IR.MUI.MED.REC.1401.006"],"award-info":[{"award-number":["IR.MUI.MED.REC.1401.006"]}],"id":[{"id":"10.13039\/501100003970","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Case Reports in Immunology"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:p>\n                    We report a novel homozygous\n                    <jats:italic>PRF1<\/jats:italic>\n                    variant,\n                    <jats:italic>PRF1<\/jats:italic>\n                    (NM_001083116.3):c.343G\u2009&gt;\u2009A (p.Glu115Lys), identified by whole\u2010exome sequencing (WES) in an 11\u2010year\u2010old girl with atypical familial hemophagocytic lymphohistiocytosis (FHL). The variant, inherited from asymptomatic heterozygous parents, was absent or extremely rare in population databases and was predicted to be deleterious by multiple in silico tools. Born to consanguineous parents, the patient presented with recurrent fever, pancytopenia, and multiorgan failure following SARS\u2010CoV\u20102 infection, further complicated by Epstein\u2013Barr virus (EBV) and cytomegalovirus (CMV) coinfections. Despite intensive immunosuppressive therapy, she developed seizures, an intracranial hemorrhage, and died at age 11.\u2009A striking family history of unexplained febrile deaths in infancy and childhood strongly supported autosomal recessive inheritance. It emphasizes the role of viral triggers, especially COVID\u201019, in revealing genetic predispositions and underscores the importance of genetic screening in atypical cases.\n                  <\/jats:p>","DOI":"10.1155\/crii\/3879317","type":"journal-article","created":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T11:39:18Z","timestamp":1770723558000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Severe COVID\u201019 Unveils Atypical Familial Hemophagocytic Lymphohistiocytosis due to a Novel Homozygous\n                    <i>PRF1<\/i>\n                    Variant"],"prefix":"10.1155","volume":"2026","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0189-7529","authenticated-orcid":false,"given":"Nasimeh","family":"Vatandoost","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7001-6794","authenticated-orcid":false,"given":"Mohsen","family":"Jari","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6565-0907","authenticated-orcid":false,"given":"Mansour","family":"Salehi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,2,10]]},"reference":[{"key":"e_1_2_11_1_2","doi-asserted-by":"crossref","first-page":"85","DOI":"10.14785\/lymphosign-2022-0014","article-title":"Whole Exome Sequencing Identifies Causative Compound Heterozygous Variants in PRF1 in Late-Onset Familial Hemophagocytic Lymphohistiocytosis","volume":"9","author":"Sham M.","year":"2022","journal-title":"LymphoSign Journal"},{"key":"e_1_2_11_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.25308"},{"key":"e_1_2_11_3_2","doi-asserted-by":"publisher","DOI":"10.1177\/00045632231186076"},{"key":"e_1_2_11_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00431-006-0258-1"},{"key":"e_1_2_11_5_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms25052762"},{"key":"e_1_2_11_6_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI40732"},{"key":"e_1_2_11_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2249.2010.04302.x"},{"key":"e_1_2_11_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2009.09.005"},{"key":"e_1_2_11_9_2","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddi076"},{"key":"e_1_2_11_10_2","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.34307"},{"key":"e_1_2_11_11_2","doi-asserted-by":"crossref","first-page":"1399","DOI":"10.1007\/s15010-022-01786-y","article-title":"Hemophagocytic Lymphohistiocytosis After SARS-CoV-2 Vaccination","volume":"50","author":"Hieber M. 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