{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T10:45:48Z","timestamp":1782470748117,"version":"3.54.5"},"reference-count":12,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T00:00:00Z","timestamp":1782432000000},"content-version":"vor","delay-in-days":176,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Case Reports in Immunology"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:p>Bee pollen has become an increasingly popular dietary supplement due to potential therapeutic effects. However, ingestion has been shown to trigger allergic responses as severe as anaphylaxis. This case highlights allergic asthma development in a 26\u2010year\u2010old female patient with subsequent anaphylaxis secondary to bee pollen ingestion. This patient presented to the emergency department with complaints of lip and tongue swelling, dyspnea, nausea, abdominal pain, and itching 4\u2009h after bee pollen ingestion. Her medical history included seasonal allergic rhinitis and prior exercise\u2010induced asthma that had not required treatment for 10 years. She was treated with a standard anaphylaxis pharmacological regimen and discharged. The patient then began to experience dyspnea and wheezing 1 month later during peak fall pollen levels. On allergy testing, the patient\u2019s total serum immunoglobulin E (IgE) was elevated at 189\u2009kU\/L. She also had elevated specific IgE to common ragweed, mugwort, and cocklebur, which are prominent allergens in the fall. Given the timing of onset of new symptoms, partial relief with an inhaled short\u2010acting B2 agonist, and no pertinent findings for other causes, the patient was subsequently diagnosed with allergic asthma secondary to bee pollen ingestion. Although anaphylaxis to bee pollen is rare, it is becoming increasingly reported in literature and demonstrates an adverse effect that can occur when proper regulation and education are not performed. Dietary supplements like bee pollen need to have further testing and contain more thorough warnings on labels to decrease adverse events and protect people from undue harm.<\/jats:p>","DOI":"10.1155\/crii\/9583906","type":"journal-article","created":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T09:47:06Z","timestamp":1782467226000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Supplemental Bee Pollen Ingestion With Resultant Anaphylaxis and Allergic Asthma: Case Report"],"prefix":"10.1155","volume":"2026","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-1576-3038","authenticated-orcid":false,"given":"Erin","family":"Eickholt","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-3622-8113","authenticated-orcid":false,"given":"Victoria","family":"Norelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathleen","family":"Martin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina","family":"Diioia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,26]]},"reference":[{"key":"e_1_2_9_1_2","doi-asserted-by":"publisher","DOI":"10.3389\/fnut.2024.1371672"},{"key":"e_1_2_9_2_2","doi-asserted-by":"crossref","DOI":"10.3390\/foods11213454","article-title":"Allergenicity Alleviation of Bee Pollen by Enzymatic Hydrolysis: Regulation in Mice Allergic Mediators, Metabolism, and Gut Microbiota","volume":"11","author":"Tao Y.","year":"2022","journal-title":"Foods"},{"key":"e_1_2_9_3_2","doi-asserted-by":"publisher","DOI":"10.3390\/nu14142858"},{"key":"e_1_2_9_4_2","unstructured":"MedlinePlus Allergic Asthma: Medlineplus Genetics 2026 https:\/\/medlineplus.gov\/genetics\/condition\/allergic-asthma\/."},{"key":"e_1_2_9_5_2","doi-asserted-by":"crossref","DOI":"10.3390\/ijms262412074","article-title":"Ensuring the Safe Use of Bee Products: A Review of Allergic Risks and Management","volume":"26","author":"Matuszewska-Mach E.","year":"2025","journal-title":"International Journal of Molecular Sciences"},{"key":"e_1_2_9_6_2","doi-asserted-by":"crossref","DOI":"10.3390\/children12050573","article-title":"Sensitization Patterns to Aeroallergens and Food Allergens Among Children With Atopic Asthma in Southwestern Saudi Arabia","volume":"12","author":"Asseri A. A.","year":"2025","journal-title":"Children"},{"key":"e_1_2_9_7_2","doi-asserted-by":"publisher","DOI":"10.12932\/AP-240324-1826"},{"key":"e_1_2_9_8_2","doi-asserted-by":"crossref","DOI":"10.1016\/j.tifs.2020.02.001","article-title":"Composition and Functionality of Bee Pollen: A Review: Performance Analytics","volume":"98","author":"Thakur M.","year":"2020","journal-title":"Trends in Food Science & Technology"},{"key":"e_1_2_9_9_2","doi-asserted-by":"crossref","DOI":"10.5415\/apallergy.2022.12.e23","article-title":"A Paediatric Case of Exercise-Augmented Anaphylaxis Following Bee Pollen Ingestion in Western Australia","volume":"12","author":"Leang Z. X.","year":"2022","journal-title":"Asia Pacific Allergy"},{"key":"e_1_2_9_10_2","doi-asserted-by":"crossref","DOI":"10.1155\/2015\/297425","article-title":"Bee Pollen: Chemical Composition and Therapeutic Application","volume":"2015","author":"Komosinska-Vassev K.","year":"2015","journal-title":"Evidence-Based Complementary and Alternative Medicine: eCAM"},{"key":"e_1_2_9_11_2","unstructured":"DermNet Compositae Allergy. Sesquiterpene Lactone Contact Allergy 2024 https:\/\/dermnetnz.org\/topics\/compositae-allergy."},{"key":"e_1_2_9_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.waojou.2023.100799"}],"container-title":["Case Reports in Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/crii\/9583906","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1155\/crii\/9583906","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/crii\/9583906","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T09:47:13Z","timestamp":1782467233000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/crii\/9583906"}},"subtitle":[],"editor":[{"given":"Kapil","family":"Sirohi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":12,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["10.1155\/crii\/9583906"],"URL":"https:\/\/doi.org\/10.1155\/crii\/9583906","archive":["Portico"],"relation":{},"ISSN":["2090-6609","2090-6617"],"issn-type":[{"value":"2090-6609","type":"print"},{"value":"2090-6617","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"2026-02-08","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-05","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-26","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"9583906"}}