{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T13:51:18Z","timestamp":1791553878981,"version":"4.3.4"},"reference-count":19,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T00:00:00Z","timestamp":1791504000000},"content-version":"vor","delay-in-days":281,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Case Reports in Nephrology"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>\n                      Myelodysplastic syndromes (MDS) may be overlooked in patients undergoing hemodialysis (HD) because anemia is commonly attributed to renal anemia and treated with erythropoiesis\u2010stimulating agents. MDS is also associated with an increased risk of bacterial infections due to neutropenia and qualitative immune dysfunction. We report recurrent invasive methicillin\u2010susceptible\n                      <jats:italic>Staphylococcus aureus<\/jats:italic>\n                      (MSSA) infections in a patient undergoing HD with concomitant MDS.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case Presentation<\/jats:title>\n                    <jats:p>The patient was a 76\u2010year\u2010old man undergoing HD for end\u2010stage kidney disease due to nephrosclerosis who was referred to our hospital because of persistent anemia despite high\u2010dose darbepoetin alfa therapy. He had a history of CHOP therapy for diffuse large B\u2010cell lymphoma, and his MDS was considered possibly therapy related. Bone marrow aspiration revealed trilineage dysplasia and 3.4% blasts without chromosomal abnormalities, leading to a diagnosis of MDS with multilineage dysplasia. Approximately 1\u2009year later, he developed persistent fever. Blood cultures yielded MSSA, and imaging studies revealed septic pulmonary embolism and multiple cerebral infarctions. He improved after intravenous cefepime therapy. Twenty\u2010two months later, he developed fever and left shoulder pain. Contrast\u2010enhanced computed tomography revealed an abscess in the left subscapularis muscle, and MSSA was isolated from the drainage fluid after CT\u2010guided drainage. He improved with drainage and antibiotic therapy. In both episodes, the neutrophil count was preserved.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      This case illustrates recurrent invasive MSSA infections in a non\u2010neutropenic HD patient with possibly therapy\u2010related MDS. HD\u2010related factors should be carefully evaluated as common causes of recurrent\n                      <jats:italic>S. aureus<\/jats:italic>\n                      infection, and MDS may represent an additional, unproven host factor. MDS should be considered in ESA\u2010resistant anemia in HD patients, particularly in those with a history of cytotoxic chemotherapy.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1155\/crin\/1023646","type":"journal-article","created":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T13:11:31Z","timestamp":1791551491000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Recurrent Invasive\n                    <i>Staphylococcus aureus<\/i>\n                    Infections in a Non\u2010Neutropenic Hemodialysis Patient With Myelodysplastic Syndrome: A Case Report"],"prefix":"10.1155","volume":"2026","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2651-1509","authenticated-orcid":false,"given":"Keisuke","family":"Ono","sequence":"first","affiliation":[{"name":"Department of Nephrology and Rheumatology Kyorin University School of Medicine  Tokyo Japan  kyorin-u.ac.jp"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nobuhiro","family":"Ayuzawa","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Rheumatology Kyorin University School of Medicine  Tokyo Japan  kyorin-u.ac.jp"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takahisa","family":"Kawakami","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Rheumatology Kyorin University School of Medicine  Tokyo Japan  kyorin-u.ac.jp"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koichi","family":"Taniwaki","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Rheumatology Kyorin University School of Medicine  Tokyo Japan  kyorin-u.ac.jp"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-6324-0286","authenticated-orcid":false,"given":"Shiori","family":"Arai","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Rheumatology Kyorin University School of Medicine  Tokyo Japan  kyorin-u.ac.jp"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aoi","family":"Kanematsu","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Rheumatology Kyorin University School of Medicine  Tokyo Japan  kyorin-u.ac.jp"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuki","family":"Suhara","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Rheumatology Kyorin University School of Medicine  Tokyo Japan  kyorin-u.ac.jp"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitsumasa","family":"Kishimoto","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Rheumatology Kyorin University School of Medicine  Tokyo Japan  kyorin-u.ac.jp"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2047-4900","authenticated-orcid":false,"given":"Yoshinori","family":"Komagata","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Rheumatology Kyorin University School of Medicine  Tokyo Japan  kyorin-u.ac.jp"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,9]]},"reference":[{"key":"e_1_2_10_1_2","doi-asserted-by":"publisher","DOI":"10.1056\/nejmra0902908"},{"key":"e_1_2_10_2_2","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1016\/j.kint.2025.06.006","article-title":"KDIGO 2026 Clinical Practice Guideline for the Management of Anemia in Chronic Kidney Disease (CKD)","volume":"109","author":"Kidney Disease: Improving Global Outcomes (KDIGO) Anemia Work Group","year":"2026","journal-title":"Kidney 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