{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T22:16:07Z","timestamp":1773008167173,"version":"3.50.1"},"reference-count":14,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T00:00:00Z","timestamp":1772150400000},"content-version":"vor","delay-in-days":57,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Case Reports in Nephrology"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The coexistence of antineutrophil cytoplasmic antibodies (ANCAs) and antiglomerular basement membrane (anti\u2010GBM) antibodies defines a rare but clinically significant autoimmune overlap syndrome. This dual positivity can result in rapidly progressive glomerulonephritis, often with poor kidney outcomes. Diagnosis is particularly challenging in patients with underlying systemic autoimmune diseases, such as Sj\u00f6gren\u2019s disease, where overlapping immunopathogenic mechanisms may obscure the clinical picture. Prompt recognition and individualized treatment are critical for optimal management.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case Presentation<\/jats:title>\n                    <jats:p>We describe a 62\u2010year\u2010old woman with a history of primary Sj\u00f6gren\u2019s disease who presented with acute kidney injury and urinary abnormalities. Serologic tests revealed high titers of myeloperoxidase (MPO)\u2013ANCA and anti\u2010GBM antibodies, as well as ANA and anti\u2010Ro\/La positivity. Kidney biopsy demonstrated crescentic glomerulonephritis with linear IgG deposition and significant chronic changes. Immunosuppressive therapy with high\u2010dose corticosteroids was initiated; however, due to advanced fibrosis and glomerulosclerosis, further immunosuppression was not pursued. The patient required dialysis but remained clinically stable during follow\u2010up.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This case highlights the diagnostic and therapeutic challenges of dual ANCA and anti\u2010GBM antibody positivity in the context of systemic autoimmunity. In patients with autoimmune disorders such as Sj\u00f6gren\u2019s disease, a high index of suspicion is essential to detect this rare overlap, which often presents with severe kidney impairment. Although kidney prognosis is frequently poor, early identification and appropriate intervention are vital for improving clinical outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1155\/crin\/2593770","type":"journal-article","created":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T20:16:00Z","timestamp":1773000960000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Intersecting Autoimmunities: ANCA and Anti\u2010GBM Overlap in a Patient With Sj\u00f6gren\u2019s Disease"],"prefix":"10.1155","volume":"2026","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6908-2508","authenticated-orcid":false,"given":"Mayra","family":"Estacio","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9533-6214","authenticated-orcid":false,"given":"Joaqu\u00edn","family":"Rodelo-Ceballos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3441-1305","authenticated-orcid":false,"given":"Ligia","family":"Calderon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5662-7983","authenticated-orcid":false,"given":"Alejandra","family":"Taborda-Murillo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,2,27]]},"reference":[{"key":"e_1_2_9_1_2","doi-asserted-by":"publisher","DOI":"10.3390\/jcm11092573"},{"key":"e_1_2_9_2_2","first-page":"251","article-title":"Sequential Development of Systemic Vasculitis With Anti-Neutrophil Cytoplasmic Antibodies Complicating Anti-Glomerular Basement Membrane Disease","volume":"32","author":"O\u2019Donoghue D. 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