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We report a 75\u2010year\u2010old female with relapsing primary FSGS successfully treated with a dual regimen of tacrolimus and mycophenolate mofetil (MMF) without steroids or cyclophosphamide. Following three years of combination therapy, with concurrent renin\u2013angiotensin system and sodium\u2013glucose cotransporter\u20102 inhibition, the patient achieved sustained remission with proteinuria &lt; 500\u2009mg\/day, without complications. This case underscores the potential of tacrolimus and MMF as a steroid\u2010sparing strategy in managing refractory FSGS. Further research is needed to validate this approach in larger patient populations.<\/jats:p>","DOI":"10.1155\/crin\/4805412","type":"journal-article","created":{"date-parts":[[2025,11,24]],"date-time":"2025-11-24T08:48:35Z","timestamp":1763974115000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Successful Management of Relapsing Primary Focal Segmental Glomerulosclerosis With Tacrolimus and Mycophenolate Multitarget 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