{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T15:27:53Z","timestamp":1791041273050,"version":"4.1.0"},"reference-count":23,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,2,26]],"date-time":"2025-02-26T00:00:00Z","timestamp":1740528000000},"content-version":"vor","delay-in-days":56,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Case Reports in Nephrology"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:p>Systemic lupus erythematosus is a systemic autoimmune pathology that generally presents in young people and manifests acutely, while its late presentation in people over 50\u2009years of age is rare and insidious. Vasculitis is a pathology that affects any vessel producing fibrinoid necrosis, and presents with a positive antineutrophil cytoplasmic antibody. The concomitance of these two entities is rare and leads to worse clinical outcomes. We present a 73\u2010year\u2010old female patient who presented with rapidly progressive glomerulonephritis requiring renal replacement therapy, pulmonary tuberculosis, late\u2010onset lupus erythematosus with lupus nephritis, and a positive result for neutrophil cytoplasmic antibody. An immune\u2010mediated extracapillary proliferative glomerulonephritis was found when the biopsy was performed, with obvious signs of vasculitis, an overlap syndrome was found between these entities. She was initially treated with antituberculosis therapy, boluses of methylprednisolone and continued with intermittent renal replacement therapy; however, due to the severity of his pathologies, she had a fatal outcome. The concomitance between these autoimmune pathologies is unusual; there is a late\u2010onset overlap syndrome between lupus nephritis accompanied by myeloperoxidase\u2010antineutrophil cytoplasmic antibody and pauci\u2010immune glomerulonephritis. The dual presentation establishes clinical challenges for its diagnosis as well as the initiation of immunosuppressive therapy when there are additional infectious pathologies.<\/jats:p>","DOI":"10.1155\/crin\/5285961","type":"journal-article","created":{"date-parts":[[2025,3,12]],"date-time":"2025-03-12T01:47:18Z","timestamp":1741744038000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Overlap Syndrome in Late\u2010Onset Systemic Lupus Erythematosus With Lupus Nephritis and MPO\u2010ANCA Pauci\u2010Immune Glomerulonephritis and Tuberculosis: An Uncommon Association"],"prefix":"10.1155","volume":"2025","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1542-2786","authenticated-orcid":false,"given":"Jaime Arturo","family":"Dulce Mu\u00f1oz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9222-3257","authenticated-orcid":false,"given":"Gustavo Jos\u00e9","family":"Aroca Mart\u00ednez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-8550-8320","authenticated-orcid":false,"given":"Christian David","family":"Seni Hern\u00e1ndez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8821-6428","authenticated-orcid":false,"given":"Diana Marcela","family":"Perea Rojas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0768-2441","authenticated-orcid":false,"given":"Omar","family":"Cabarcas Barbosa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-5533-4897","authenticated-orcid":false,"given":"Lucia Mercedes","family":"Ni\u00f1o Hern\u00e1ndez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-4897-7378","authenticated-orcid":false,"given":"Dario Jose","family":"Gaivao Arciniegas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-0191-7872","authenticated-orcid":false,"given":"Camila Mar\u00eda","family":"Garc\u00eda Jarava","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-6801-3805","authenticated-orcid":false,"given":"Marianela","family":"Olivares Olmos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-8098-6530","authenticated-orcid":false,"given":"Sebastian Andre","family":"Seni Hern\u00e1ndez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-5263-0795","authenticated-orcid":false,"given":"Valentina","family":"P\u00e9rez Jim\u00e9nez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2601-2363","authenticated-orcid":false,"given":"Indiana Luz","family":"Rojas Torres","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,2,26]]},"reference":[{"key":"e_1_2_9_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.semarthrit.2008.10.007"},{"key":"e_1_2_9_2_2","doi-asserted-by":"crossref","DOI":"10.22265\/acnef.6.2.370","article-title":"Caracterizaci\u00f3n Cl\u00ednica de Pacientes con nefropat\u00eda l\u00fapica en Santander, la Importancia de la biopsia Renal","volume":"6","author":"Torres-Bustamante M.","year":"2019","journal-title":"Revista Colombiana de Nefrolog\u00eda"},{"key":"e_1_2_9_3_2","doi-asserted-by":"publisher","DOI":"10.1177\/0961203319864168"},{"key":"e_1_2_9_4_2","volume-title":"Henrys Clinical Diagnosis and Management by Laboratory Methods 23e","author":"Richard A.","year":"2017"},{"key":"e_1_2_9_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.medcli.2020.05.009"},{"key":"e_1_2_9_6_2","doi-asserted-by":"crossref","DOI":"10.1016\/S0121-8123(09)70103-3","article-title":"Epidemiolog\u00eda de las Vasculitis Primarias en Colombia y su Relaci\u00f3n con lo Informado para Latinoam\u00e9rica","volume":"16","author":"Ochoa C. 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