{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T22:21:42Z","timestamp":1788042102540,"version":"build-2784847793"},"reference-count":20,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T00:00:00Z","timestamp":1773273600000},"content-version":"vor","delay-in-days":70,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Case Reports in Nephrology"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:sec>\n                    <jats:label\/>\n                    <jats:p>Hidradenitis suppurativa (HS) (Verneuil\u2019s disease) is a chronic inflammatory cutaneous disorder with systemic inflammatory potential. A rare and severe sequela of this sustained inflammation is reactive (AA) amyloidosis, typically presenting with nephrotic\u2010range proteinuria and progressive renal failure. Here, we report a 50\u2010year\u2010old male with severe (Hurley Stage III) HS who developed nephrotic syndrome secondary to biopsy\u2010proven renal AA amyloidosis. Initiation of the TNF\u2010\u03b1 inhibitor adalimumab induced a dramatic concurrent improvement in both cutaneous and renal disease activities. Proteinuria declined from a baseline of 9\/24 to 2\u2009g\/24\u2009h at 4\u2009months and subsequently to 0.9\u2009g\/24\u2009h at 10\u2009months, signifying a near\u2010complete nephrotic remission.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>This case underscores the dual therapeutic mechanism of TNF\u2010\u03b1 blockade in this context: reducing systemic inflammation and preventing amyloid deposition, with improvement in renal prognosis. There is literature corroborating the usefulness of TNF\u2010\u03b1 inhibitors in early\u2010stage AA amyloidosis. The application of adalimumab early in severe forms of HS may avert AA amyloidosis\u2013related renal involvement or renal function decline. We suggest implementing systematic screening for significant proteinuria in patients with advanced HS (Hurley II\/III) to facilitate timely diagnosis and therapeutic intervention to preserve renal function.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1155\/crin\/5476216","type":"journal-article","created":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T05:55:36Z","timestamp":1773381336000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Adalimumab for AA Amyloidosis Secondary to Severe Hidradenitis Suppurativa"],"prefix":"10.1155","volume":"2026","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5041-9243","authenticated-orcid":false,"given":"Ghalia","family":"Khellaf","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Souad","family":"Chelghoum","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Houria","family":"Sahel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rym Hadj","family":"Sahraoui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nacima","family":"Djennane","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Benziane","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,3,12]]},"reference":[{"key":"e_1_2_12_1_2","doi-asserted-by":"publisher","DOI":"10.5414\/cn110577"},{"key":"e_1_2_12_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0140-6736(24)02475-9"},{"key":"e_1_2_12_3_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-157-12-201212180-00004"},{"key":"e_1_2_12_4_2","article-title":"Hidradenitis Suppurativa: Where We Are and Where We Are Going","volume":"10","author":"Scala E. 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