{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,26]],"date-time":"2026-05-26T07:02:16Z","timestamp":1779778936811,"version":"3.53.1"},"reference-count":17,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,5,25]],"date-time":"2026-05-25T00:00:00Z","timestamp":1779667200000},"content-version":"vor","delay-in-days":144,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Case Reports in Nephrology"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:p>IgA nephropathy (IgAN), or Berger\u2019s disease, is the most common primary glomerulopathy worldwide. It is characterized by dominant mesangial deposition of immunoglobulin A1 (IgA1), typically of the galactose\u2010deficient form (Gd\u2010IgA1), which triggers the formation of circulating immune complexes and subsequent glomerular inflammation. Clinical presentation includes hematuria, proteinuria, and, in severe cases, progressive renal failure. A rare variant is the extracapillary or crescentic form, which follows an aggressive course. We report the case of a 52\u2010year\u2010old woman with a history of Stage II right\u2010sided infiltrating ductal breast carcinoma, treated in 2023 with radical mastectomy, AC\u2010T chemotherapy, and radiotherapy. Complete oncologic remission was confirmed by SPECT imaging. In January 2025, with a known baseline creatinine of 1.2\u2009mg\/dL, the patient presented with macroscopic hematuria, hypertension, and rapid decline in renal function. Workup revealed subnephrotic proteinuria (1854\u2009mg\/24\u2009h), active urinary sediment with 65% dysmorphic erythrocytes and red blood cell casts, and a creatinine peak of 4.7\u2009mg\/dL. Autoimmune serologies were negative. Kidney biopsy showed IgAN with cellular crescents in 64% of glomeruli and an Oxford classification of M0 E0 S1T1 C2. Immunofluorescence confirmed mesangial IgA and C3 deposits. Despite treatment with intravenous methylprednisolone, cyclophosphamide, and oral prednisone, yet no renal recovery was achieved, and the patient remains on chronic hemodialysis. To our knowledge, this is the first reported case in Bolivia of extracapillary IgAN occurring after breast cancer remission, highlighting a rare clinical association and raising the possibility of an underlying immune\u2010mediated link between malignancy and crescentic IgAN, without establishing causality.<\/jats:p>","DOI":"10.1155\/crin\/5546873","type":"journal-article","created":{"date-parts":[[2026,5,26]],"date-time":"2026-05-26T06:03:21Z","timestamp":1779775401000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Rapidly Progressive IgA Nephropathy in a Patient With a History of Breast Cancer: A Case Report and Literature Review"],"prefix":"10.1155","volume":"2026","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-4603-0817","authenticated-orcid":false,"given":"Roger Leon","family":"Montesinos","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edwin Quispe","family":"Marca","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carla Arnez","family":"Torrico","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel Segura","family":"Herbas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis C\u00e9spedes","family":"Limachi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zulma Tapia","family":"Arenas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wilder Villca","family":"Mamani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,25]]},"reference":[{"key":"e_1_2_9_1_2","doi-asserted-by":"publisher","DOI":"10.1056\/nejmra020109"},{"key":"e_1_2_9_2_2","first-page":"211","article-title":"Natural History of IgA Nephropathy and Risk Factors for Progression: a long-term follow-up Study","volume":"379","author":"Lv J.","year":"2012","journal-title":"Lancet"},{"key":"e_1_2_9_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0272-6386(97)90456-x"},{"key":"e_1_2_9_4_2","first-page":"425","article-title":"Steroid Therapy for Patients with IgA Nephropathy and Crescent Formation","volume":"7","author":"Lv J.","year":"2012","journal-title":"Clinical Journal of the American Society of Nephrology"},{"key":"e_1_2_9_5_2","first-page":"1236","article-title":"Secondary IgA Nephropathy and IgA-dominant Immune Complex Disease","volume":"6","author":"Glassock R. 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H.","year":"2012","journal-title":"Clinical Journal of the American Society of Nephrology"},{"key":"e_1_2_9_15_2","first-page":"89","article-title":"Protein Electrophoresis: Interpretation in Clinical Practice","volume":"22","author":"Cuppari L.","year":"2000","journal-title":"J Bras Nefrol"},{"key":"e_1_2_9_16_2","first-page":"2005","article-title":"Prediction of Outcomes in IgA Nephropathy by the Oxford Classification: Validation in a Chinese Cohort","volume":"7","author":"Lv J.","year":"2012","journal-title":"Clinical Journal of the American Society of Nephrology"},{"key":"e_1_2_9_17_2","article-title":"Rapidly Progressive IgA Nephropathy in a Patient with a History of Breast Cancer: Abstract Presented at the World Congress of Nephrology","author":"Leon R.","year":"2026","journal-title":"Kidney International Reports"}],"container-title":["Case Reports in Nephrology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/crin\/5546873","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1155\/crin\/5546873","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/crin\/5546873","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,26]],"date-time":"2026-05-26T06:03:25Z","timestamp":1779775405000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/crin\/5546873"}},"subtitle":[],"editor":[{"given":"Poorani","family":"Gurumallesh Prabu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":17,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["10.1155\/crin\/5546873"],"URL":"https:\/\/doi.org\/10.1155\/crin\/5546873","archive":["Portico"],"relation":{},"ISSN":["2090-6641","2090-665X"],"issn-type":[{"value":"2090-6641","type":"print"},{"value":"2090-665X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"2025-08-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-24","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-25","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"5546873"}}