{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T21:05:15Z","timestamp":1773781515361,"version":"3.50.1"},"reference-count":35,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,9,2]],"date-time":"2025-09-02T00:00:00Z","timestamp":1756771200000},"content-version":"vor","delay-in-days":244,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Case Reports in Nephrology"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:p>\n                    <jats:bold>Introduction:<\/jats:bold>\n                    Renal AA amyloidosis with X\u2010linked hyper\u2010IgM immunodeficiency is rare diseases, and their simultaneous presentation in the same patient is exceptional.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Case Presentation:<\/jats:bold>\n                    We present a case of renal AA amyloidosis in a 20\u2010year\u2010old man with nephrotic syndrome and reduced glomerular filtration rate (GFR). Clinically, serologically, histopathological, and genetically, we confirm renal amyloidosis in the presence of X\u2010linked hyper\u2010IgM syndrome; in turn, we detected a new hemizygous pathogenic variant in the CD40L gene (c.345delA).\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusion:<\/jats:bold>\n                    Our hypothesis suggests that these conditions predisposed the patient to a combined (cellular and humoral) immunodeficiency, leading to recurrent infectious episodes throughout his life, ultimately resulting in renal amyloidosis due to deposition of serum amyloid protein.\n                  <\/jats:p>","DOI":"10.1155\/crin\/6664645","type":"journal-article","created":{"date-parts":[[2025,9,3]],"date-time":"2025-09-03T05:50:22Z","timestamp":1756878622000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Acquired Renal Amyloidosis in a Patient With X\u2010Linked Hyper\u2010IgM Immunodeficiency With Novel Hemizygotic Pathogenic Variant in CD40LG Gene"],"prefix":"10.1155","volume":"2025","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8428-2740","authenticated-orcid":false,"given":"Daniel","family":"Celis-Giraldo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3768-8278","authenticated-orcid":false,"given":"Deider Steeven","family":"Garc\u00eda-Villamizar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-7811-5040","authenticated-orcid":false,"given":"Camilo","family":"Parra-Amaris","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2997-6993","authenticated-orcid":false,"given":"Diana Carolina","family":"Guti\u00e9rrez-Gonz\u00e1lez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4534-6086","authenticated-orcid":false,"given":"Daniel","family":"Rodr\u00edguez-Peralta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,9,2]]},"reference":[{"key":"e_1_2_10_1_2","doi-asserted-by":"publisher","DOI":"10.1159\/000506696"},{"key":"e_1_2_10_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11926-024-01147-8"},{"key":"e_1_2_10_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/joim.13169"},{"key":"e_1_2_10_4_2","doi-asserted-by":"publisher","DOI":"10.1056\/nejmra2304088"},{"key":"e_1_2_10_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.rdc.2018.06.004"},{"key":"e_1_2_10_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mayocp.2020.06.029"},{"key":"e_1_2_10_7_2","doi-asserted-by":"publisher","DOI":"10.1080\/13506129.2017.1342235"},{"key":"e_1_2_10_8_2","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/860208"},{"key":"e_1_2_10_9_2","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.31976"},{"key":"e_1_2_10_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2020.09.023"},{"key":"e_1_2_10_11_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-pathol-020712-163913"},{"key":"e_1_2_10_12_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1707120114"},{"key":"e_1_2_10_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.clim.2018.11.007"},{"key":"e_1_2_10_14_2","doi-asserted-by":"publisher","DOI":"10.1093\/cei\/uxac110"},{"key":"e_1_2_10_15_2","doi-asserted-by":"publisher","DOI":"10.1080\/08820139.2018.1493052"},{"key":"e_1_2_10_16_2","doi-asserted-by":"publisher","DOI":"10.1615\/critrevimmunol.v37.i2-6.100"},{"key":"e_1_2_10_17_2","doi-asserted-by":"publisher","DOI":"10.1101\/2023.07.23.550231"},{"key":"e_1_2_10_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.clim.2023.109692"},{"key":"e_1_2_10_19_2","first-page":"1993","volume-title":"Genereviews","author":"Dunn C. 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